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Details on Person MYC/MYCN bind the ALK gene

Class:Id	Reaction:9725332
_displayName	MYC/MYCN bind the ALK gene
_doRelease	TRUE
_timestamp	2021-05-04 17:35:15
authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9725331] Rothfels, Karen, 2021-03-29
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input	[DefinedSet:3215043] MYC,MYCN [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9725096] ALK gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9725081] ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma [LiteratureReference:9725232] Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells [LiteratureReference:9723836] Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification [LiteratureReference:9725295] Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells [LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
modified	[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MYC/MYCN bind the ALK gene
output	[Complex:9725109] MYC/MYCN:ALK gene [nucleoplasm] [Homo sapiens]
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9725333] R-HSA-9725332.2
summation	[Summation:9725330] MYC and MYCN bind to E boxes in the ALK promoter region to d...
(hasEvent)	[Pathway:201556] Signaling by ALK [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9725117] ALK gene expression [Homo sapiens]
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No pathways have been reviewed or authored by MYC/MYCN bind the ALK gene (9725332)