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Details on Person NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1

Class:Id	Reaction:9725023
_displayName	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1
_doRelease	TRUE
_timestamp	2023-10-12 19:31:21
authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9725022] Rothfels, Karen, 2021-03-26
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input	[Complex:9725002] CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] [Homo sapiens] [Complex:9725012] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9724945] NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry [LiteratureReference:9724982] Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA) [LiteratureReference:9724967] Proteomic Phosphosite Analysis Identified Crucial NPM-ALK-Mediated NIPA Serine and Threonine Residues [LiteratureReference:9724987] Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M
modified	[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9850956] Rothfels, Karen, 2023-10-12
name	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1
output	[Complex:9725021] NPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9725009] NPM1-ALK translocates to the nucleus [Homo sapiens] [Reaction:9700181] Autophosphorylation of ALK fusions [Homo sapiens]
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9725025] R-HSA-9725023.3
summation	[Summation:9725018] ZC3HC1, also known as NIPA (nuclear interacting partner of a...
(hasEvent)	[Pathway:9725371] Nuclear events stimulated by ALK signaling in cancer [Homo sapiens]
(precedingEvent)	[Reaction:9725030] MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner [Homo sapiens]
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No pathways have been reviewed or authored by NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 (9725023)