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Details on Person NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]

Class:Id	EntityWithAccessionedSequence:9725010
_displayName	NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
_timestamp	2023-03-30 12:08:50
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9725011] Rothfels, Karen, 2021-03-26
disease	[Disease:6802338] lymphoma [Disease:1500689] cancer
endCoordinate	117
hasModifiedResidue	[FragmentInsertionModification:9699804] Insertion of residues 1058 to 1620 at 118 from UniProt:Q9UM73 ALK [ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278 [ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282 [ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283 [ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096 [ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1359 [ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507 [ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
literatureReference	[LiteratureReference:9699651] Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
modified	[InstanceEdit:9832284] Orlic-Milacic, Marija, 2023-03-30
name	NPM1(1-117)-p-7Y-ALK(1058-1620) fusion Nucleophosmin B23 NPM_HUMAN
referenceEntity	[ReferenceGeneProduct:402515] UniProt:P06748 NPM1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9725014] R-HSA-9725010.2
startCoordinate	1
(hasComponent)	[Complex:9725012] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9905706] Update Tracker - [EntityWithAccessionedSequence:9725010] NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] - v85:[modifyName]
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No pathways have been reviewed or authored by NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (9725010)