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Details on Person Unique so far among ALK fusion proteins, NPM1-ALK is partial...
| Class:Id | Summation:9725008 |
|---|---|
| _displayName | Unique so far among ALK fusion proteins, NPM1-ALK is partial... |
| _timestamp | 2021-03-26 16:38:46 |
| created | [InstanceEdit:9725011] Rothfels, Karen, 2021-03-26 |
| text | Unique so far among ALK fusion proteins, NPM1-ALK is partially nuclear in localization. Endogenous full length NPM is a nuclear-cytoplasmic shuttling protein that contains a nuclear localization signal; although this domain is not conserved in the NPM-ALK fusion, nuclear localization of NPM-ALK is believed to be facilitated by oligomerization with full-length NPM, which exists in dimeric and pentameric states (Kim et al, 2015; reviewed in Box et al ,2006; Okuwaki, 2007; Ducray et al, 2019). Partial nuclear localization of NPM-ALK allows it to perform roles in transcriptional and epigenetic regulation (reviewed in Ducray et al, 2019). |
| (summation) | [BlackBoxEvent:9725009] NPM1-ALK translocates to the nucleus [Homo sapiens] |
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No pathways have been reviewed or authored by Unique so far among ALK fusion proteins, NPM1-ALK is partial... (9725008)
