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Details on Person PPM1A, PPM1B dephosphorylate TBK1 or IKBKE

Class:Id	Reaction:9724201
_displayName	PPM1A, PPM1B dephosphorylate TBK1 or IKBKE
_doRelease	FALSE
_timestamp	2023-05-18 14:08:38
catalystActivity	[CatalystActivity:9724198] protein serine/threonine phosphatase activity of PPM1A, PPM1B [cytosol]
catalystActivityReference	[CatalystActivityReference:9724194] protein serine/threonine phosphatase activity of PPM1A, PPM1B [cytosol] PPM1B negatively regulates antiviral response via dephosphorylating TBK1
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9724202] Shamovsky, Veronica, 2021-03-23
goBiologicalProcess	[GO_BiologicalProcess:261603] negative regulation of type I interferon production
input	[SimpleEntity:29356] H2O [cytosol] [Complex:9710999] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9724208] PPM1B negatively regulates antiviral response via dephosphorylating TBK1 [LiteratureReference:9731447] PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1
modified	[InstanceEdit:9731450] Shamovsky, Veronica, 2021-05-20 [InstanceEdit:9835839] Shamovsky, Veronica, 2023-05-18
name	PPM1A, PPM1B dephosphorylate TBK1 or IKBKE
output	[SimpleEntity:113550] Pi [nucleoplasm] [Complex:9705133] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] [Homo sapiens]
precedingEvent	[Reaction:9705320] TBK1, IKBKE are autophosphorylated at Ser172 [Homo sapiens] [Reaction:9705137] TBK1 or IKBKE forms homodimers [Homo sapiens]
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9724224] R-HSA-9724201.1
summation	[Summation:9724212] Phosphorylation of TBK1 and IKBKE at Ser172 is essential for...
(hasEvent)	[Pathway:9717624] Regulators of DDX58/IFIH1 signaling [Homo sapiens]
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No pathways have been reviewed or authored by PPM1A, PPM1B dephosphorylate TBK1 or IKBKE (9724201)