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Details on Person Rothfels, Karen, 2021-03-22
| Class:Id | InstanceEdit:9724129 |
| _displayName | Rothfels, Karen, 2021-03-22 |
| _timestamp | 2021-03-22 19:37:32 |
| author | [Person:1226097] Rothfels, Karen |
| dateTime | 2021-03-22 19:37:25 |
| (authored) | [FailedReaction:9700114] NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 [Homo sapiens] [Reaction:9700131] ALK mutants bind type I TKIs [Homo sapiens] [Reaction:9700179] Ligand-independent dimerization of ALK fusions [Homo sapiens] [Reaction:9700181] Autophosphorylation of ALK fusions [Homo sapiens] [Reaction:9700184] Ligand-independent dimerization of point mutants of ALK [Homo sapiens] [Reaction:9700186] Autophosphorylation of point mutants of ALK [Homo sapiens] [Reaction:9700190] ALK mutants bind SHC [Homo sapiens] [Reaction:9700193] ALK mutants phosphorylate SHC1 [Homo sapiens] [Pathway:9700206] Signaling by ALK in cancer [Homo sapiens] [Pathway:9700645] ALK mutants bind TKIs [Homo sapiens] |
| (modified) | [PathwayDiagram:9700218] Diagram of Signaling by ALK, Signaling by ALK fusions and activated point mutants, ALK mutants bind TKIs, ASP-3026- resistant ALK mutants, NVP-TAE684-resistant ALK mutants, alectinib resistant ALK mutants, brigatinib-resistant ALK mutants, ceritinib-resistant ALK mutants, crizotinib-resistant ALK mutants, and lorlatinib-resistant ALK mutants [Summation:9701517] Tyrosine phosphorylation at residue 705 is required for STAT... [EntityWithAccessionedSequence:9710854] CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] [Homo sapiens] [Reaction:9710917] ALK fusion proteins bind PLCG1 [Homo sapiens] [Summation:9711767] PI3K phosphorylates PIP2 to PIP3 downstream of activated ALK... [Complex:9711928] ALK mutants:PIK3R1 [cytosol] [Homo sapiens] [CandidateSet:9711929] PI3K-binding ALK mutants [cytosol] [Homo sapiens] [CandidateSet:9711944] STAT3-activating ALK mutants [cytosol] [Homo sapiens] [BlackBoxEvent:9712078] ALK mutants bind PI3KR1 [Homo sapiens] [Reaction:9712079] ALK mutants bind STAT3 [Homo sapiens] |
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No pathways have been reviewed or authored by Rothfels, Karen, 2021-03-22 (9724129)