Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person ALK mutants:p-3Y SHC binds GRB2

Class:IdReaction:9724099
_displayNameALK mutants:p-3Y SHC binds GRB2
_doReleaseTRUE
_timestamp2021-05-04 17:33:28
authored[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
compartment[Compartment:70101] cytosol
created[InstanceEdit:9724101] Rothfels, Karen, 2021-03-22
disease[Disease:1500689] cancer
edited[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input[Complex:9699971] ALK fusion dimers:p-3Y SHC1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:8983328] GRB2 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9699651] Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
[LiteratureReference:9699672] Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity
[LiteratureReference:9710719] A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma
[LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
[LiteratureReference:9718441] The role of the ALK receptor in cancer biology
modified[InstanceEdit:9724130] Rothfels, Karen, 2021-03-22
[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30
[InstanceEdit:9729893] Rothfels, Karen, 2021-05-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameALK mutants:p-3Y SHC binds GRB2
output[Complex:9724097] ALK fusion dimers:p-3Y SHC1:GRB2 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2021-06-09
reviewed[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9724102] R-HSA-9724099.2
summation[Summation:9724100] GRB2 is found in complex with SHC in cells expressing a numb...
(hasEvent)[Pathway:9725370] Signaling by ALK fusions and activated point mutants [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by ALK mutants:p-3Y SHC binds GRB2 (9724099)