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Details on Person Defective TP53 does not tetramerize

Class:Id	FailedReaction:9723906
_displayName	Defective TP53 does not tetramerize
_doRelease	TRUE
_timestamp	2021-05-03 13:21:31
authored	[InstanceEdit:9726526] Orlic-Milacic, Marija, 2021-04-07
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9723904] Orlic-Milacic, Marija, 2021-03-18
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9729597] Orlic-Milacic, Marija, 2021-05-03
entityFunctionalStatus	[EntityFunctionalStatus:9726239] loss_of_function and partial_loss_of_function of TP53 mutants (tetramerization) [nucleoplasm]
input	[CandidateSet:9720037] TP53 mutants (tetramerization) [nucleoplasm] [Homo sapiens] [CandidateSet:9720037] TP53 mutants (tetramerization) [nucleoplasm] [Homo sapiens] [CandidateSet:9720037] TP53 mutants (tetramerization) [nucleoplasm] [Homo sapiens] [CandidateSet:9720037] TP53 mutants (tetramerization) [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9726064] Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function [LiteratureReference:9726103] p53 mutants without a functional tetramerisation domain are not oncogenic [LiteratureReference:9726113] Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus [LiteratureReference:9726245] Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome [LiteratureReference:9726252] Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells [LiteratureReference:9726286] Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members [LiteratureReference:9726293] Characterization of p53 mutants identified in human tumors with a missense mutation in the tetramerization domain [LiteratureReference:9726301] A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer [LiteratureReference:9726305] Stability and structural recovery of the tetramerization domain of p53-R337H mutant induced by a designed templating ligand [LiteratureReference:9726313] Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivation [LiteratureReference:6804858] p53 oligomerization and DNA looping are linked with transcriptional activation
modified	[InstanceEdit:9726078] Orlic-Milacic, Marija, 2021-04-05 [InstanceEdit:9726108] Orlic-Milacic, Marija, 2021-04-05 [InstanceEdit:9726117] Orlic-Milacic, Marija, 2021-04-05 [InstanceEdit:9726131] Orlic-Milacic, Marija, 2021-04-05 [InstanceEdit:9726247] Orlic-Milacic, Marija, 2021-04-06 [InstanceEdit:9726262] Orlic-Milacic, Marija, 2021-04-06 [InstanceEdit:9726290] Orlic-Milacic, Marija, 2021-04-06 [InstanceEdit:9726294] Orlic-Milacic, Marija, 2021-04-06 [InstanceEdit:9726302] Orlic-Milacic, Marija, 2021-04-06 [InstanceEdit:9726312] Orlic-Milacic, Marija, 2021-04-06 [InstanceEdit:9726317] Orlic-Milacic, Marija, 2021-04-06 [InstanceEdit:9726349] Orlic-Milacic, Marija, 2021-04-06 [InstanceEdit:9726374] Orlic-Milacic, Marija, 2021-04-07 [InstanceEdit:9729597] Orlic-Milacic, Marija, 2021-05-03 [InstanceEdit:9729600] Orlic-Milacic, Marija, 2021-05-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective TP53 does not tetramerize
normalReaction	[Reaction:6804762] TP53 forms homotetramers [Homo sapiens]
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729599] Sakaguchi, Kazuyasu, 2021-04-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9723910] R-HSA-9723906.2
summation	[Summation:9726370] A number of nonsense and frameshift truncations result in mu...
(hasEvent)	[Pathway:9723905] Loss of function of TP53 in cancer due to loss of tetramerization ability [Homo sapiens]
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