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Details on Person holo-FDPS dimer binds NBPs

Class:IdReaction:9717841
_displayNameholo-FDPS dimer binds NBPs
_doReleaseTRUE
_timestamp2022-05-10 17:57:58
authored[InstanceEdit:9717837] Jassal, Bijay, 2021-03-15
compartment[Compartment:70101] cytosol
created[InstanceEdit:9717837] Jassal, Bijay, 2021-03-15
edited[InstanceEdit:9717837] Jassal, Bijay, 2021-03-15
[InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input[Complex:981570] holo-FDPS dimer [cytosol] [Homo sapiens]
[DefinedSet:9717840] NBPs [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9717861] Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase
[LiteratureReference:9717875] Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism
[LiteratureReference:9717886] Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase
[LiteratureReference:9717870] Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
[LiteratureReference:9717989] Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
[LiteratureReference:9717973] Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid
modified[InstanceEdit:9717978] Jassal, Bijay, 2021-03-16
[InstanceEdit:9773229] Matthews, Lisa, 2022-05-03
[InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
[InstanceEdit:9773858] Matthews, Lisa, 2022-05-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameholo-FDPS dimer binds NBPs
holo-FDPS dimer binds FDPS inhibitors
output[Complex:9717836] holo-FDPS dimer:NBPs [cytosol] [Homo sapiens]
releaseDate2022-06-09
reviewed[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9717851] R-HSA-9717841.2
summation[Summation:9717972] The mevalonate pathway is responsible for the biosynthesis o...
(hasEvent)[Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
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No pathways have been reviewed or authored by holo-FDPS dimer binds NBPs (9717841)
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