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Details on Person GGPS1 hexamer transfers IPPP to DMAPP

Class:Id	Reaction:9717834
_displayName	GGPS1 hexamer transfers IPPP to DMAPP
_doRelease	TRUE
_timestamp	2025-06-06 20:51:47
authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:9717831] dimethylallyltranstransferase activity of holo-GGPS1 hexamer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9717837] Jassal, Bijay, 2021-03-15
crossReference	[DatabaseIdentifier:9945091] RHEA:22409
edited	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
input	[SimpleEntity:191324] DMAPP [cytosol] [SimpleEntity:191362] IPPP [cytosol]
literatureReference	[LiteratureReference:191398] Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. [LiteratureReference:191275] Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression [LiteratureReference:981558] The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs [LiteratureReference:9717838] Structure, catalysis, and inhibition mechanism of prenyltransferase
modified	[InstanceEdit:9730937] Jassal, Bijay, 2021-05-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9945102] D'Eustachio, Peter, 2025-04-10 [InstanceEdit:9954123] D'Eustachio, Peter, 2025-06-06
name	GGPS1 hexamer transfers IPPP to DMAPP isopentenyl diphosphate + dimethylallyl diphosphate => (2E)-geranyl diphosphate + diphosphate Addition of isopentenyl pyrophosphate to DMAPP
output	[SimpleEntity:191409] GPP [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:191382] Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate [Homo sapiens] [Reaction:191414] MVD decarboxylates MVA5PP to IPPP [Homo sapiens] [Reaction:191414] MVD decarboxylates MVA5PP to IPPP [Homo sapiens] [Reaction:191422] Mevalonate-5-phosphate is further phosphorylated [Homo sapiens]
releaseDate	2007-02-20
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9717849] R-HSA-9717834.4
summation	[Summation:191364] The prenyltransferase enzyme family is involved in the biosy...
(hasEvent)	[Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:191303] FDPS dimer transfers IPPP to GPP [Homo sapiens] [Reaction:9717830] GGPS1 hexamer transfers IPPP to GPP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971815] Update Tracker - [Reaction:9717834] GGPS1 hexamer transfers IPPP to DMAPP - v95:[modifyText]
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No pathways have been reviewed or authored by GGPS1 hexamer transfers IPPP to DMAPP (9717834)