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Details on Person Antiviral innate immune response receptor RIG-I (RIG-1, DDX5...
| Class:Id | Summation:9717594 |
|---|---|
| _displayName | Antiviral innate immune response receptor RIG-I (RIG-1, DDX5... |
| _timestamp | 2021-03-16 05:47:40 |
| created | [InstanceEdit:9717591] Shamovsky, Veronica, 2021-03-13 |
| literatureReference | [LiteratureReference:9717589] Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling [LiteratureReference:9717611] Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production [LiteratureReference:9717593] Conventional protein kinase C-α (PKC-α) and PKC-β negatively regulate RIG-I antiviral signal transduction [LiteratureReference:9717893] Phosphorylation of RIG-I by casein kinase II inhibits its antiviral response |
| modified | [InstanceEdit:9717892] Shamovsky, Veronica, 2021-03-16 |
| text | Antiviral innate immune response receptor RIG-I (RIG-1, DDX58) signaling is regulated by a dynamic balance between phosphorylation and dephosphorylation of CARDs and repressor domain (RD) of DDX58. While phosphorylation of DDX58 at S8 and T170 inhibited downstream signaling in human embryonic kidney 293T (HEK293T) cells and human monocytic THP-1 cells (Nistal-Villán E et al. 2010; Maharaj NP et al. 2012), dephosphorylation of DDX58 by PPP1CA and PPP1CC activated DDX58 to elicit immune signaling upon RNA virus infections (Wies E et al. 2013). Similar findings were reported in the studies with DDX58 phosphorylated at S854, S855 and T770 by casein kinase II in HEK293T cells and human umbilical vein endothelial cells (HUVEC) (Sun Z et al. 2011). Inhibition of phosphatase activity decreased virus-induced IFN-β production in human cells in a dose-dependent manner (Sun Z et al. 2011; Wies E et al. 2013). |
| (summation) | [Reaction:9717588] Dephosphorylation of DDX58 [Homo sapiens] |
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No pathways have been reviewed or authored by Antiviral innate immune response receptor RIG-I (RIG-1, DDX5... (9717594)
