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Details on Person UniProt:P04543 1B
| Class:Id | ReferenceGeneProduct:9717527 |
|---|---|
| _chainChangeLog | chain:1-124 for 9717527 added on Thu May 6 2021 |
| _displayName | UniProt:P04543 1B |
| _timestamp | 2024-11-03 20:20:27 |
| chain | chain:1-124 |
| checksum | C14DF0FE9C9E5512 |
| comment | FUNCTION Plays a major role in antagonizing the type I IFN-mediated antiviral response (PubMed:15047850). Acts cooperatively with NS1 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3 (PubMed:15827150). Interacts with the host cytoplasmic sensor of viral nucleic acids RIGI and prevents the interaction with its downstream partner MAVS (PubMed:19193793). Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C (PubMed:17251292, PubMed:23877405). The degradasome requires an intact mitochondrial MAVS (PubMed:23877405). Induces host SOCS1 expression (PubMed:26557722). Induces activation of NF-kappa-B. Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism promoting continued viral replication (PubMed:17151097).SUBUNIT Monomer (instable) (PubMed:8864205). Homomultimer (PubMed:8864205). Heteromultimer with NS1 (PubMed:21795342). Interacts with host RIGI (via N-terminus); this interaction prevents host signaling pathway involved in interferon production (PubMed:19193793). Interacts with host MAP1B/microtubule-associated protein 1B (PubMed:21795342).INTERACTION Most NS2 resides in the mitochondria as a heteromer with NS1.DOMAIN The DNLP motif has IFN suppressive functions like binding to host MAP1B.SIMILARITY Belongs to the pneumovirus non-structural protein 2 family. |
| created | [InstanceEdit:9717460] Shamovsky, Veronica, 2021-03-10 |
| description | recommendedName: Non-structural protein 2 shortName: NS2 alternativeName: Non-structural protein 1B |
| geneName | 1B NS2 |
| identifier | P04543 |
| isSequenceChanged | FALSE |
| keyword | Host mitochondrion Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host interferon signaling pathway by virus Inhibition of host IRF3 by virus Inhibition of host IRF7 by virus Inhibition of host RIG-I by virus Inhibition of host RLR pathway by virus Inhibition of host STAT2 by virus Inhibition of host TBK1 by virus Inhibition of host TLR pathway by virus Interferon antiviral system evasion Modulation of host cell apoptosis by virus Viral immunoevasion |
| modified | [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | 1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NS2_HRSVA Q77YB6 |
| sequenceLength | 124 |
| species | [Species:9717528] Human respiratory syncytial virus A |
| (referenceEntity) | [EntityWithAccessionedSequence:9717498] NS2 [cytosol] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9832561] NS2 [mitochondrial matrix] [Human respiratory syncytial virus A] |
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No pathways have been reviewed or authored by UniProt:P04543 1B (9717527)
