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Details on Person TRPM4 transports Na+ from the extracellular region to the cytosol

Class:Id	Reaction:9717383
_displayName	TRPM4 transports Na+ from the extracellular region to the cytosol
_doRelease	TRUE
_timestamp	2021-08-08 13:14:09
authored	[InstanceEdit:9717388] May, Bruce, 2021-03-10
catalystActivity	[CatalystActivity:9717376] calcium-activated cation channel activity of TRPM4 tetramer [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9717391] May, Bruce, 2021-03-10
edited	[InstanceEdit:9717388] May, Bruce, 2021-03-10
inferredFrom	[Reaction:9717432] Trpm4 transports Na+ from the extracellular region to the cytosol [Mus musculus]
input	[SimpleEntity:74113] Na+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:3296345] TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization
modified	[InstanceEdit:9717459] May, Bruce, 2021-03-10 [InstanceEdit:9724888] May, Bruce, 2021-03-25 [InstanceEdit:9731339] May, Bruce, 2021-05-19 [InstanceEdit:9749950] May, Bruce, 2021-08-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRPM4 transports Na+ from the extracellular region to the cytosol
output	[SimpleEntity:83910] Na+ [cytosol]
precedingEvent	[Reaction:9717215] ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol [Homo sapiens] [Reaction:9717214] I(1,4,5)P3 binds ITPR3 tetramer [Homo sapiens]
regulatedBy	[PositiveRegulation:71542] Positive regulation by 'Ca2+ [cytosol]'
releaseDate	2021-09-15
reviewed	[InstanceEdit:9749949] Jiang, Peihua, 2021-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9717423] R-HSA-9717383.2
summation	[Summation:9724840] TRPM4 is activated by calcium ions and passively transports ...
(hasEvent)	[Pathway:9717207] Sensory perception of sweet, bitter, and umami (glutamate) taste [Homo sapiens]
(precedingEvent)	[Reaction:9717392] CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region [Homo sapiens]
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No pathways have been reviewed or authored by TRPM4 transports Na+ from the extracellular region to the cytosol (9717383)