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Details on Person UniProt:B1ASB6 Spocd1
| Class:Id | ReferenceGeneProduct:9715666 |
|---|---|
| _chainChangeLog | chain:1-1015 for 9715666 added on Wed February 17 2021 |
| _displayName | UniProt:B1ASB6 Spocd1 |
| _timestamp | 2025-02-21 18:52:03 |
| chain | chain:1-1015 |
| checksum | 12986EDA44CA9A89 |
| comment | FUNCTION Protein adapter that acts as an essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:32674113, PubMed:38359823, PubMed:39294378). Recruited to young transposons, which are specifically marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3), via its association with SPIN1 chromatin reader, and associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (PubMed:32674113, PubMed:39294378). Following this, PIWIL4 engages with nascent transposable element transcript to direct piRNA-directed DNA methylation (PubMed:39294378). Not required for piRNA biosynthesis (PubMed:32674113).SUBUNIT Interacts with DNMT3A, DNMT3C and DNMT3L (PubMed:32674113). Interacts with C19orf84 homolog (PubMed:38359823). Interacts with SPIN1; promoting recruitment to transposons marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed:39294378).SUBCELLULAR LOCATION Detected in embryonic testis at 14.5 dpc and decreases by postnatal day 5.DISRUPTION PHENOTYPE Male mice are infertile with spermatozoa completely absent in the epididymis (PubMed:32674113). Male germ cells show derepression of transposable elements (TEs) and DNA hypomethylation of TEs (PubMed:32674113). |
| created | [InstanceEdit:9715482] Weiser, JD |
| description | recommendedName: fullName evidence="7"SPOC domain-containing protein 1 |
| geneName | Spocd1 |
| identifier | B1ASB6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chromosome Differentiation Nucleus Reference proteome RNA-mediated gene silencing Spermatogenesis |
| modified | [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Spocd1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SPOC1_MOUSE |
| sequenceLength | 1015 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9727508] Spocd1 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:B1ASB6 Spocd1 (9715666)
