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Details on Person UniProt:Q06BI3-1 Caln1
| Class:Id | ReferenceIsoform:9715488 |
|---|---|
| _chainChangeLog | chain:1-261 for 9715488 added on Wed February 17 2021 |
| _displayName | UniProt:Q06BI3-1 Caln1 |
| _timestamp | 2023-11-03 18:22:06 |
| chain | chain:1-261 |
| checksum | D38AE0DFBBAE38D9 |
| comment | FUNCTION Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning.SUBUNIT Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner.SUBCELLULAR LOCATION Brain-specific. High expression in the cerebellum, hippocampus, and cortex.DOMAIN The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting.MISCELLANEOUS Calcium binding induces conformational changes in CALN1/CABP8. The calcium binding affinity is not regulated by magnesium. |
| created | [InstanceEdit:9715482] Weiser, JD |
| description | recommendedName: Calcium-binding protein 8 shortName: CaBP8 alternativeName: Calneuron I alternativeName: Calneuron-1 |
| geneName | Caln1 Cabp8 |
| identifier | Q06BI3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Cell membrane Cytoplasm Golgi apparatus Membrane Metal-binding Reference proteome Repeat Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Caln1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CABP8_RAT Q06BI2 |
| sequenceLength | 261 |
| species | [Species:48895] Rattus norvegicus |
| variantIdentifier | Q06BI3-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q06BI3-1 Caln1 (9715488)
