Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P04413 US3
| Class:Id | ReferenceGeneProduct:9715395 |
|---|---|
| _chainChangeLog | chain:1-481 for 9715395 added on Wed February 17 2021 |
| _displayName | UniProt:P04413 US3 |
| _timestamp | 2025-08-15 21:35:11 |
| chain | chain:1-481 |
| checksum | 71838AB0483BE055 |
| comment | FUNCTION Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and inhibition of host immune response (PubMed:25907557, PubMed:31249678, PubMed:34935440). Phosphorylates UL31 and UL34, two critical regulators of capsid budding from nucleus to endoplasmic reticulum, thereby facilitating virion egress (PubMed:15994828, PubMed:1656069). Modulates and redistributes host components of the nuclear envelope, including LMNA, emerin/EMD and the nuclear matrix protein MATR3 (PubMed:20962082). In turn, facilitates nuclear pore impairment and capsid release through impaired nuclear envelope (PubMed:31249678). Phosphorylates envelope glycoprotein B (gB), probably to direct it to the cell surface (PubMed:19846518). Promotes virus intracellular spread by restructuring host cell cytoskeleton. Blocks host apoptosis to extend cell survival and allow efficient viral replication. Promotes viral gene expression by phosphorylating host HDAC2 to reduce viral genome silencing (PubMed:20660201). Strongly inhibits TCR-activated signal transduction in T-cells by reducing the ubiquitination of LAT and TRAF6, leading to a suboptimal activation of LAT (PubMed:25907557). Subverts host antiviral innate immunity by inhibiting type I interferon production through hyperphosphorylation of beta-catenin/CTNNB1 (PubMed:31801859). In addition, phosphorylates the RNA sensor RIGI and the transcription factor IRF3 to prevent the RLR-mediated antiviral signaling pathway (PubMed:24049179, PubMed:34935440). Hyperphosphorylates host RELA and thereby dampens NF-kappa-B signaling (PubMed:24807716). Acts as an immunoevasin partly responsible for inhibition of MR1 expression and antigen presentation in response to bacterial infection.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts with host LAT; this interaction prevents LAT activation of TRAF6 (PubMed:25907557).SUBCELLULAR LOCATION Phosphorylated by UL13; this phosphorylation regulates subsequent phosphorylation of UL31 and UL34 by US3. Autophosphorylated.SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. |
| created | [InstanceEdit:9715437] Shamovsky, Veronica, 2021-02-17 |
| description | recommendedName: Serine/threonine-protein kinase US3 ecNumber: 2.7.11.1 |
| geneName | US3 |
| identifier | P04413 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Host cytoplasm Host nucleus Host-virus interaction Kinase Modulation of host cell apoptosis by virus Modulation of host chromatin by virus Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | US3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | US03_HHV11 |
| sequenceLength | 481 |
| species | [Species:5689680] Human herpesvirus 1 |
| (referenceEntity) | [EntityWithAccessionedSequence:9715417] US3 [cytosol] [Human herpesvirus 1] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P04413 US3 (9715395)
