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Details on Person p- 7Y ALK L1122V [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9715294
_displayName	p- 7Y ALK L1122V [plasma membrane]
_timestamp	2021-02-17 00:35:06
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9715288] Rothfels, Karen, 2021-02-17
crossReference	[DatabaseIdentifier:9715227] COSMIC:COSM9311665
disease	[Disease:1247848] non-small cell lung carcinoma
endCoordinate	1620
hasModifiedResidue	[ReplacedResidue:9715212] L-leucine 1122 replaced with L-valine [ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096 [ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278 [ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282 [ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283 [ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1359 [ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507 [ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
literatureReference	[LiteratureReference:9714001] Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma
name	p- 7Y ALK L1122V ALK tyrosine kinase receptor ALK_HUMAN
referenceEntity	[ReferenceGeneProduct:49894] UniProt:Q9UM73 ALK [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9715305] R-HSA-9715294.1
startCoordinate	19
(hasComponent)	[Complex:9715328] p- 7Y ALK L1122V dimer [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by p- 7Y ALK L1122V [plasma membrane] (9715294)