Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person The following ALK mutants show resistance to brigatinib:

AL...

Class:IdSummation:9714031
_displayNameThe following ALK mutants show resistance to brigatinib:

AL...
_timestamp2021-03-08 22:37:12
created[InstanceEdit:9714026] Rothfels, Karen, 2021-02-02
modified[InstanceEdit:9715236] Rothfels, Karen, 2021-02-17
[InstanceEdit:9717348] Rothfels, Karen, 2021-03-08
textThe following ALK mutants show resistance to brigatinib:

ALK L1122V: Ceccon et al, 2015
ALK I1171N: Ceccon et al, 2013
ALK 1171S: Amin et al, 2016
ALK I1171T: Katayama et al, 2021 (moderate)
ALK L1196M: Sharma et al, 2019; Ceccon et al, 2015 (moderate)
ALK L1198F: Ceccon et al, 2015
ALK G1202R: Sharma et al, 2019; Gainor et al, 2016
ALK D1203N: Gainor et al, 2016
ALK S1206C: Ceccon et al, 2015
(summation)[FailedReaction:9715356] brigatinib-resistant ALK mutants don't bind brigatinib [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by The following ALK mutants show resistance to brigatinib:

AL... (9714031)