Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Anti-cancer drugs generate DNA interstrand crosslinks

Class:IdBlackBoxEvent:9713785
_displayNameAnti-cancer drugs generate DNA interstrand crosslinks
_doReleaseTRUE
_timestamp2021-08-11 12:30:29
authored[InstanceEdit:9713846] Orlic-Milacic, Marija, 2021-02-01
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9713788] Orlic-Milacic, Marija, 2021-02-01
edited[InstanceEdit:9750078] Orlic-Milacic, Marija, 2021-08-09
inferredFrom
input[GenomeEncodedEntity:5649637] dsDNA [nucleoplasm] [Homo sapiens]
[DefinedSet:9713797] DNA crosslinking anti-cancer drugs [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:6786163] DNA interstrand crosslink repair and cancer
[LiteratureReference:9713830] The evolving role of DNA inter-strand crosslinks in chemotherapy
[LiteratureReference:9736495] Antibody-drug conjugates (ADCs) delivering pyrrolobenzodiazepine (PBD) dimers for cancer therapy
[LiteratureReference:9736497] Interactions of mitomycin C with mammalian DNA detected by alkaline elution
[LiteratureReference:9736458] DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate
[LiteratureReference:9736429] Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells
[LiteratureReference:9736494] Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay
[LiteratureReference:9736462] Gene and human tumour cell line specific differencesin nitrogen mustard induced DNA alkylation and interstrand crosslinking frequencies
[LiteratureReference:9736445] Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines
[LiteratureReference:9736453] Comparative pharmacokinetics of DNA lesion formation and removal following treatment of L1210 cells with nitrogen mustards
[LiteratureReference:9736428] Formation of DNA adducts by the anticancer drug carboplatin: different nucleotide sequence preferences in vitro and in cells
[LiteratureReference:9736506] Formation and repair of DNA interstrand cross-links in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated with cis-diamminedichloroplatinum(II)
[LiteratureReference:9736457] Sequence- and region-specificity of oxaliplatin adducts in naked and cellular DNA
[LiteratureReference:9736455] Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex, cis-[amminedichloro(2-methylpyridine)] platinum(II) (AMD473)
[LiteratureReference:9736482] DNA-binding properties of novel cis- and trans platinum-based anticancer agents in 2 human ovarian carcinoma cell lines
[LiteratureReference:9736480] Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity
[LiteratureReference:9736476] Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload
[LiteratureReference:9736463] SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML
[LiteratureReference:9616000] Balancing repair and tolerance of DNA damage caused by alkylating agents
[LiteratureReference:9736554] The role of the N-(hydroxymethyl)melamines as antitumour agents: mechanism of action studies
[LiteratureReference:9736559] Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas
[LiteratureReference:9736560] Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity
[LiteratureReference:9736569] Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis-diamminedichloroplatinum(II) in human glial-derived cell lines
[LiteratureReference:9750089] In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473
[LiteratureReference:9750110] Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
[LiteratureReference:9750099] Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA
modified[InstanceEdit:9713834] Orlic-Milacic, Marija, 2021-02-01
[InstanceEdit:9736413] Orlic-Milacic, Marija, 2021-07-09
[InstanceEdit:9736508] Orlic-Milacic, Marija, 2021-07-12
[InstanceEdit:9736576] Orlic-Milacic, Marija, 2021-07-12
[InstanceEdit:9750086] Orlic-Milacic, Marija, 2021-08-09
[InstanceEdit:9750091] Orlic-Milacic, Marija, 2021-08-09
[InstanceEdit:9750107] Orlic-Milacic, Marija, 2021-08-09
[InstanceEdit:9750108] Orlic-Milacic, Marija, 2021-08-09
[InstanceEdit:9750124] Orlic-Milacic, Marija, 2021-08-09
[InstanceEdit:9750125] Orlic-Milacic, Marija, 2021-08-09
[InstanceEdit:9750278] Orlic-Milacic, Marija, 2021-08-11
[InstanceEdit:9750283] Orlic-Milacic, Marija, 2021-08-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAnti-cancer drugs generate DNA interstrand crosslinks
output[GenomeEncodedEntity:6785117] ICL-DNA [nucleoplasm] [Homo sapiens]
releaseDate2021-09-15
reviewed[InstanceEdit:9749858] Kadambat Nair, Sisira, 2021-07-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9713809] R-HSA-9713785.2
summation[Summation:9713833] Some of the earliest and still most widely used anti-cancer ...
(hasEvent)[Pathway:9750126] Drug-induced formation of DNA interstrand crosslinks [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Anti-cancer drugs generate DNA interstrand crosslinks (9713785)
Follow Reactome