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Details on Person ALK fusions phosphorylate FRS

Class:IdReaction:9712087
_displayNameALK fusions phosphorylate FRS
_doReleaseTRUE
_timestamp2021-05-04 17:32:48
authored[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
catalystActivity[CatalystActivity:9711941] protein tyrosine kinase activity of ALK fusions:FRS [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9712080] Rothfels, Karen, 2021-01-14
disease[Disease:1500689] cancer
edited[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input[Complex:9711938] ALK fusions:FRS [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9699705] Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation
[LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease
[LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
[LiteratureReference:9711816] The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment
modified[InstanceEdit:9724130] Rothfels, Karen, 2021-03-22
[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30
[InstanceEdit:9729893] Rothfels, Karen, 2021-05-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameALK fusions phosphorylate FRS
output[Complex:9712069] ALK fusions:p-6Y FRS [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2021-06-09
reviewed[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9712094] R-HSA-9712087.2
summation[Summation:9711763] FRS proteins are phosphorylated downstream of ALK fusions in...
(hasEvent)[Pathway:9725370] Signaling by ALK fusions and activated point mutants [Homo sapiens]
(updatedInstance)[_UpdateTracker:9853280] Update Tracker - [Reaction:9712087] ALK fusions phosphorylate FRS - v87:[modifyText]
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