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Details on Person ALK fusions phosphorylate IRS1

Class:IdReaction:9712082
_displayNameALK fusions phosphorylate IRS1
_doReleaseTRUE
_timestamp2021-05-04 17:32:52
authored[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
catalystActivity[CatalystActivity:9711936] protein tyrosine kinase activity of IRS:ALK fusion proteins [cytosol]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9712080] Rothfels, Karen, 2021-01-14
disease[Disease:1500689] cancer
edited[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input[SimpleEntity:113592] ATP [cytosol]
[Complex:9711940] IRS:ALK fusion proteins [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9699651] Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
[LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition
[LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer
[LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
modified[InstanceEdit:9724130] Rothfels, Karen, 2021-03-22
[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30
[InstanceEdit:9729893] Rothfels, Karen, 2021-05-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameALK fusions phosphorylate IRS1
output[SimpleEntity:29370] ADP [cytosol]
[Complex:9712076] p-Y IRS1:ALK fusion proteins [cytosol] [Homo sapiens]
precedingEvent
releaseDate2021-06-09
reviewed[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9712097] R-HSA-9712082.2
summation[Summation:9711764] IRS1 is phosphorylated downstream of NPM-ALK fusions (Fujimo...
(hasEvent)[Pathway:9725370] Signaling by ALK fusions and activated point mutants [Homo sapiens]
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No pathways have been reviewed or authored by ALK fusions phosphorylate IRS1 (9712082)