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Details on Person Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib
| Class:Id | LiteratureReference:9711845 |
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| _displayName | Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib |
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| _timestamp | 2021-01-13 21:48:03 |
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| author | [Person:9702252] Ou, Sai-Hong Ignatius
[Person:9634510] Klempner, Samuel J
[Person:9711796] Greenbowe, Joel R
[Person:9702299] Azada, Michele
[Person:9634495] Schrock, Alexa B
[Person:5655437] Ali, Siraj M
[Person:6800598] Ross, Jeffrey S
[Person:6800609] Stephens, Philip J
[Person:6800578] Miller, Vincent A |
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| created | [InstanceEdit:9711838] Rothfels, Karen, 2021-01-13 |
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| journal | J Thorac Oncol |
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| pages | 1821-5 |
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| pubMedIdentifier | 25393796 |
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| title | Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib |
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| volume | 9 |
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| year | 2014 |
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| (literatureReference) | [Reaction:9700131] ALK mutants bind type I TKIs [Homo sapiens]
[Reaction:9700179] Ligand-independent dimerization of ALK fusions [Homo sapiens]
[FailedReaction:9700656] alectinib resistant ALK mutants don't bind alectinib [Homo sapiens]
[DefinedSet:9700529] crizotinib-sensitive ALK mutants [cytosol] [Homo sapiens]
[DefinedSet:9700555] alectinib sensitve ALK mutants [plasma membrane] [Homo sapiens]
[DefinedSet:9700560] alectinib resistant ALK mutants [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9711956] HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9711970] HIP1(1-1019)-ALK(1058-1620) [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib (9711845)
