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Details on Person ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol]

Class:Id	EntityWithAccessionedSequence:9710833
_displayName	ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol]
_timestamp	2023-03-30 12:08:40
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9710843] Rothfels, Karen, 2021-01-05
disease	[Disease:9699595] anaplastic large cell lymphoma
endCoordinate	230
hasModifiedResidue	[FragmentInsertionModification:9710840] Insertion of residues 1059 to 1620 at 231 from UniProt:Q9UM73 ALK [ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096 [ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278 [ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282 [ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283 [ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1359 [ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507 [ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
literatureReference	[LiteratureReference:9710779] Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis [LiteratureReference:9710719] A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma
modified	[InstanceEdit:9832284] Orlic-Milacic, Marija, 2023-03-30
name	ATIC(1-230)-p-7Y-ALK(1059-1620) fusion Bifunctional purine biosynthesis protein ATIC PUR9_HUMAN
referenceEntity	[ReferenceGeneProduct:62507] UniProt:P31939 ATIC [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9710861] R-HSA-9710833.2
startCoordinate	1
(hasComponent)	[Complex:9710873] ATIC(1-230)-p-7Y ALK(1059-1620) fusion dimer [cytosol] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9905646] Update Tracker - [EntityWithAccessionedSequence:9710833] ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol] - v85:[modifyName]
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No pathways have been reviewed or authored by ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol] (9710833)