Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person The GSDME gene promoter is hypermethylated

Class:Id	BlackBoxEvent:9710490
_displayName	The GSDME gene promoter is hypermethylated
_doRelease	TRUE
_timestamp	2021-04-22 23:27:18
authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
catalystActivity	[CatalystActivity:212303] methyltransferase activity of DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9710398] Shamovsky, Veronica, 2020-12-30
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:9709115] colon cancer [Disease:1614289] melanoma
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input	[SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [SimpleEntity:77087] AdoMet [nucleoplasm] [EntityWithAccessionedSequence:9710319] GSDME gene [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:9710207] Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma [LiteratureReference:9710187] DFNA5 promoter methylation a marker for breast tumorigenesis [LiteratureReference:9710162] Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer [LiteratureReference:9710153] Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer
modified	[InstanceEdit:9711034] Shamovsky, Veronica, 2021-01-07 [InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17 [InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9716691] Shamovsky, Veronica, 2021-02-23 [InstanceEdit:9728907] Shamovsky, Veronica, 2021-04-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The GSDME gene promoter is hypermethylated
output	[SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [SimpleEntity:77502] AdoHcy [nucleoplasm] [EntityWithAccessionedSequence:9710426] hyper 5-mC GSDME gene promoter [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:212222] PRC2 recruits DNA methyltransferases [Homo sapiens] [BlackBoxEvent:212252] Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9710488] Negative gene expression regulation by 'Decitabine triphosphate [nucleoplasm]'
releaseDate	2021-03-23
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715446] Zhang, Zhibin, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9710508] R-HSA-9710490.3
summation	[Summation:9710451] 5-Methylation of cytosine residues in DNA is a heritable epi...
(hasEvent)	[Pathway:9710421] Defective pyroptosis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776206] Update Tracker - [BlackBoxEvent:9710490] The GSDME gene promoter is hypermethylated - v77:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by The GSDME gene promoter is hypermethylated (9710490)