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Details on Person Decitabine triphosphate incorporates into DNA

Class:Id	Reaction:9710480
_displayName	Decitabine triphosphate incorporates into DNA
_doRelease	TRUE
_timestamp	2025-08-20 20:53:49
authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
catalystActivity	[CatalystActivity:68508] DNA-directed DNA polymerase activity of DNA polymerase alpha:primase [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9710398] Shamovsky, Veronica, 2020-12-30
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input	[SimpleEntity:29604] dATP [nucleoplasm] [SimpleEntity:30185] dCTP [nucleoplasm] [SimpleEntity:29892] dGTP [nucleoplasm] [SimpleEntity:30187] dTTP [nucleoplasm] [Complex:68423] RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm] [Homo sapiens] [ChemicalDrug:9710463] Decitabine triphosphate [nucleoplasm]
literatureReference	[Book:9710444] 9780128022085 Egger, Gerda DNA Methyltransferase Inhibitors Drug Discovery in Cancer Epigenetics
modified	[InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17 [InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9728907] Shamovsky, Veronica, 2021-04-22 [InstanceEdit:9793351] Shamovsky, Veronica, 2022-06-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9964232] Shamovsky, Veronica, 2025-08-20
name	Decitabine triphosphate incorporates into DNA
output	[Complex:9710454] RNA primer:decitabine-DNA primer:origin duplex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:68913] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin [Homo sapiens] [Reaction:68914] DNA polymerase alpha:primase binds at the origin [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715446] Zhang, Zhibin, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9710495] R-HSA-9710480.5
summation	[Summation:9710472] Cellular uptake of decitabine or 5‑aza‑2′‑deoxycytidine is m...
(hasEvent)	[Pathway:9710421] Defective pyroptosis [Homo sapiens]
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No pathways have been reviewed or authored by Decitabine triphosphate incorporates into DNA (9710480)