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Details on Person Pyroptosis is a form of lytic inflammatory programmed cell d...

Class:Id	Summation:9710422
_displayName	Pyroptosis is a form of lytic inflammatory programmed cell d...
_timestamp	2021-04-22 23:27:13
created	[InstanceEdit:9710398] Shamovsky, Veronica, 2020-12-30
literatureReference	[LiteratureReference:9710206] Gasdermins and their role in immunity and inflammation [LiteratureReference:9710262] Emerging insights on the role of gasdermins in infection and inflammatory diseases [LiteratureReference:9652641] Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases [LiteratureReference:9710286] Gasdermin D activity in inflammation and host defense [LiteratureReference:9710210] The role of pyroptosis in cancer: pro-cancer or pro-"host"? [LiteratureReference:9710185] The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer [LiteratureReference:9710448] Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes [LiteratureReference:9710413] Into the eye of the cytokine storm [LiteratureReference:9710484] The COVID-19 Cytokine Storm; What We Know So Far [LiteratureReference:9710207] Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma [LiteratureReference:9710187] DFNA5 promoter methylation a marker for breast tumorigenesis [LiteratureReference:9710162] Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer [LiteratureReference:9710153] Methylation of the DFNA5 increases risk of lymph node metastasis in human breast cancer [LiteratureReference:9710475] Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer [LiteratureReference:9710028] Gasdermin E suppresses tumour growth by activating anti-tumour immunity [LiteratureReference:9710212] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer [LiteratureReference:9710425] DNA methylation as an early diagnostic marker of cancer (Review) [LiteratureReference:9710492] DNA methylation based biomarkers in colorectal cancer: A systematic review [LiteratureReference:9710328] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer [LiteratureReference:9710446] DNA methylation in cancer: too much, but also too little [LiteratureReference:9710067] Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death [LiteratureReference:9716245] Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity? [LiteratureReference:9686122] Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin [LiteratureReference:9728821] Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells [LiteratureReference:9728910] A bioorthogonal system reveals antitumour immune function of pyroptosis [LiteratureReference:9709829] The molecular machinery of regulated cell death
modified	[InstanceEdit:9711034] Shamovsky, Veronica, 2021-01-07 [InstanceEdit:9716268] Shamovsky, Veronica, 2021-02-19 [InstanceEdit:9716275] Shamovsky, Veronica, 2021-02-19 [InstanceEdit:9716276] Shamovsky, Veronica, 2021-02-20 [InstanceEdit:9728907] Shamovsky, Veronica, 2021-04-22
text	Pyroptosis is a form of lytic inflammatory programmed cell death that is mediated by the pore‑forming gasdermins (GSDMs) (Shi J et al. 2017) to stimulate immune responses through the release of pro‑inflammatory interleukin (IL)‑1β, IL‑18 (mainly in GSDMD-mediated pyroptosis) as well as danger signals such as adenosine triphosphate (ATP) or high mobility group protein B1 (HMGB1) (reviewed in Shi J et al. 2017; Man SM et al. 2017; Tang D et al. 2019; Lieberman J et al. 2019). Pyroptosis protects the host from microbial infection but can also lead to pathological inflammation if overactivated or dysregulated (reviewed in Orning P et al. 2019; Tang L et al. 2020). During infections, the excessive production of cytokines can lead to a cytokine storm, which is associated with acute respiratory distress syndrome (ARDS) and systemic inflammatory response syndrome (SIRS) (reviewed in Tisoncik JR et al. 2012; Karki R et al. 2020; Ragab D et al. 2020). Pyroptosis has a close but complicated relationship to tumorigenesis, affected by tissue type and genetic background. Pyroptosis can trigger potent antitumor immune responses or serve as an effector mechanism in antitumor immunity (Wang Q et al. 2020; Zhou Z et al. 2020; Zhang Z et al. 2020), while in other cases, as a type of proinflammatory death, pyroptosis can contribute to the formation of a microenvironment suitable for tumor cell growth (reviewed in Xia X et al. 2019; Jiang M et al. 2020; Zhang Z et al. 2021). This Reactome module describes the defective GSDME function caused by cancer‑related GSDME mutations (Zhang Z et al. 2020). It also shows epigenetic inactivation of GSDME due to hypermethylation of the GSDME promoter region (Akino K et al. 2007; Kim MS et al. 2008a,b; Croes L et al. 2017, 2018; Ibrahim J et al. 2019). Aberrant promoter methylation is considered to be a hallmark of cancer (Ehrlich M et al. 2002; Dong Y et al. 2014; Lam K et al. 2016; Croes L et al. 2018). Treatment with the DNA methyltransferase inhibitor decitabine (5‑aza‑2'‑deoxycytidine or DAC) may elevate GSDME expression in certain cancer cells (Akino K et al. 2007; Fujikane T et al. 2009; Wang Y et al. 2017).
(summation)	[Pathway:9710421] Defective pyroptosis [Homo sapiens]
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