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Details on Person GSDMD (1-275) binds cardiolipin

Class:IdReaction:9710353
_displayNameGSDMD (1-275) binds cardiolipin
_doReleaseTRUE
_timestamp2025-08-18 19:04:23
authored[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
compartment[Compartment:70101] cytosol
[Compartment:17906] mitochondrial outer membrane
created[InstanceEdit:9710359] Shamovsky, Veronica, 2020-12-28
edited[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input[EntityWithAccessionedSequence:9647641] GSDMD(1-275) [cytosol] [Homo sapiens]
[SimpleEntity:8954419] cardiolipin [mitochondrial outer membrane]
isChimericFALSE
literatureReference[LiteratureReference:9689630] Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
[LiteratureReference:9693533] Mechanism of membrane pore formation by human gasdermin-D
[LiteratureReference:9647685] Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
[LiteratureReference:9647674] Pore-forming activity and structural autoinhibition of the gasdermin family
modified[InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17
[InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22
[InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9963990] Shamovsky, Veronica, 2025-08-18
nameGSDMD (1-275) binds cardiolipin
output[Complex:9710347] GSDMD(1-275):cardiolipin [mitochondrial outer membrane] [Homo sapiens]
precedingEvent
releaseDate2021-03-23
reviewed[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17
[InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17
[InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9710366] R-HSA-9710353.4
summation[Summation:9710361] Gasdermin D (GSDMD) is cleaved by inflammatory caspases (CAS...
(hasEvent)[Pathway:5620971] Pyroptosis [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776089] Update Tracker - [Reaction:9710353] GSDMD (1-275) binds cardiolipin - v77:[modifyText]
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