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Details on Person GSDME expression mediated by TP53, TP63

Class:Id	BlackBoxEvent:9710306
_displayName	GSDME expression mediated by TP53, TP63
_doRelease	TRUE
_timestamp	2021-04-22 04:32:16
authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9710316] Shamovsky, Veronica, 2020-12-28
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input	[EntityWithAccessionedSequence:9710319] GSDME gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9710326] The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage [LiteratureReference:9710328] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer
modified	[InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17 [InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GSDME expression mediated by TP53, TP63
output	[EntityWithAccessionedSequence:9647620] GSDME [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9710323] TP53 or TP63 binds the GSDME gene [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9710307] Positive gene expression regulation by '(p-S15,S20-TP53,TP63):GSDME gene [nucleoplasm]'
regulationReference	[RegulationReference:9710325] Positive gene expression regulation by '(p-S15,S20-TP53,TP63):GSDME gene [nucleoplasm]' The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage
releaseDate	2021-03-23
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9710333] R-HSA-9710306.3
summation	[Summation:9710305] Gasdermin E (GSDME, also known as DFNA5) was identified as a...
(hasEvent)	[Pathway:5620971] Pyroptosis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9647632] CASP3 cleaves GSDME [Homo sapiens] [BlackBoxEvent:9710263] GZMB cleaves GSDME [Homo sapiens]
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No pathways have been reviewed or authored by GSDME expression mediated by TP53, TP63 (9710306)