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Details on Person GSDMD expression mediated by IRF2, IRF1

Class:Id	BlackBoxEvent:9710294
_displayName	GSDMD expression mediated by IRF2, IRF1
_doRelease	TRUE
_timestamp	2021-04-22 04:31:58
authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9710288] Shamovsky, Veronica, 2020-12-28
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input	[EntityWithAccessionedSequence:8963121] GSDMD gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9710293] IRF2 transcriptionally induces GSDMD expression for pyroptosis
modified	[InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17 [InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GSDMD expression mediated by IRF2, IRF1
output	[EntityWithAccessionedSequence:6801577] GSDMD [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9710295] IRF2 or IRF1 binds the GSDMD gene promoter [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9710300] Positive gene expression regulation by 'IRF2, IRF1:GSDMD gene [nucleoplasm]'
regulationReference	[RegulationReference:9710291] Positive gene expression regulation by 'IRF2, IRF1:GSDMD gene [nucleoplasm]' IRF2 transcriptionally induces GSDMD expression for pyroptosis
releaseDate	2021-03-23
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9710302] R-HSA-9710294.3
summation	[Summation:9710287] Gasdermin D (GSDMD), a key protein in the activation of pyro...
(hasEvent)	[Pathway:5620971] Pyroptosis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9647680] CASP1 cleaves GSDMD [Homo sapiens] [BlackBoxEvent:9710106] ELANE cleaves GSDMD [Homo sapiens] [BlackBoxEvent:9947997] CASP5 cleaves GSDMD [Homo sapiens] [BlackBoxEvent:9948146] CASP4 cleaves GSDMD [Homo sapiens]
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No pathways have been reviewed or authored by GSDMD expression mediated by IRF2, IRF1 (9710294)