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Details on Person GZMB cleaves GSDME

Class:IdBlackBoxEvent:9710263
_displayNameGZMB cleaves GSDME
_doReleaseTRUE
_timestamp2021-04-22 04:32:23
authored[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
catalystActivity[CatalystActivity:140427] serine-type endopeptidase activity of GZMB [cytosol]
catalystActivityReference[CatalystActivityReference:9710253] serine-type endopeptidase activity of GZMB [cytosol] Gasdermin E suppresses tumour growth by activating anti-tumour immunity
compartment[Compartment:70101] cytosol
created[InstanceEdit:9710266] Shamovsky, Veronica, 2020-12-25
edited[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
input[EntityWithAccessionedSequence:9647620] GSDME [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9710028] Gasdermin E suppresses tumour growth by activating anti-tumour immunity
modified[InstanceEdit:9710337] Shamovsky, Veronica, 2020-12-28
[InstanceEdit:9715450] Shamovsky, Veronica, 2021-02-17
[InstanceEdit:9716570] Shamovsky, Veronica, 2021-02-22
[InstanceEdit:9728823] Shamovsky, Veronica, 2021-04-22
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGZMB cleaves GSDME
output[EntityWithAccessionedSequence:9647615] GSDME (271-496) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9647689] GSDME(1-270) [cytosol] [Homo sapiens]
precedingEvent
releaseDate2021-03-23
reviewed[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17
[InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17
[InstanceEdit:9728818] Shao, Feng, 2021-04-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9710268] R-HSA-9710263.3
summation[Summation:9710265] Granzyme B (GZMB) belongs to a family of serine proteases st...
(hasEvent)[Pathway:5620971] Pyroptosis [Homo sapiens]
(precedingEvent)[Reaction:9647660] GSDME (1-270) binds PIPs [Homo sapiens]
[Reaction:9710354] GSDME (1-270) binds cardiolipin [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776125] Update Tracker - [BlackBoxEvent:9710263] GZMB cleaves GSDME - v77:[modifyText]
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No pathways have been reviewed or authored by GZMB cleaves GSDME (9710263)