Query author contributions in Reactome
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Details on Person The extreme N-terminus of BRCA2, involving amino acid residu...
| Class:Id | Summation:9709618 |
|---|---|
| _displayName | The extreme N-terminus of BRCA2, involving amino acid residu... |
| _timestamp | 2020-12-16 18:25:37 |
| created | [InstanceEdit:9709619] Orlic-Milacic, Marija, 2020-12-16 |
| text | The extreme N-terminus of BRCA2, involving amino acid residues 10-40, is necessary and sufficient for PALB2 binding (Xia et al. 2006). Several germline BRCA2 missense mutations identified in breast cancer patients map to this region and impair the ability of BRCA2 recombinant constructs that include the first 60 amino acids of BRCA2 to bind to PALB2: BRCA2 G25R (severely diminished binding to PALB2, Xia et al. 2006) BRCA2 W31R (complete loss of PALB2 binding, Xia et al. 2006) BRCA2 W31C (complete loss of PALB2 binding, Xia et al. 2006) |
| (summation) | [FailedReaction:9709601] Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding [Homo sapiens] |
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No pathways have been reviewed or authored by The extreme N-terminus of BRCA2, involving amino acid residu... (9709618)
