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Details on Person Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding

Class:IdFailedReaction:9709601
_displayNameDefective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
_doReleaseTRUE
_timestamp2022-02-04 15:40:43
authored[InstanceEdit:9709291] Orlic-Milacic, Marija, 2020-12-11
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9709602] Orlic-Milacic, Marija, 2020-12-16
disease[Disease:1500689] cancer
edited[InstanceEdit:9763742] Orlic-Milacic, Marija, 2022-02-04
entityFunctionalStatus[EntityFunctionalStatus:9709612] loss_of_function and partial_loss_of_function of 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1:BCDX2 complex [nucleoplasm]
input[EntityWithAccessionedSequence:419548] PALB2 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:5685301] RAD51AP1 [nucleoplasm] [Homo sapiens]
[OtherEntity:1638790] Sister Chromatid [chromosome]
[Complex:9709610] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1:BCDX2 complex [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:517910] Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2
modified[InstanceEdit:9709617] Orlic-Milacic, Marija, 2020-12-16
[InstanceEdit:9709620] Orlic-Milacic, Marija, 2020-12-16
[InstanceEdit:9762835] Orlic-Milacic, Marija, 2022-01-28
[InstanceEdit:9763682] Orlic-Milacic, Marija, 2022-02-03
[InstanceEdit:9763683] Orlic-Milacic, Marija, 2022-02-03
[InstanceEdit:9763732] Orlic-Milacic, Marija, 2022-02-04
[InstanceEdit:9763743] Orlic-Milacic, Marija, 2022-02-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
normalReaction
releaseDate2022-03-23
reviewed[InstanceEdit:9763679] Liu, Jie, 2022-01-26
[InstanceEdit:9763678] Le, Hang Phuong, 2022-01-26
[InstanceEdit:9763681] Heyer, Wolf-Dietrich, 2022-01-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9709604] R-HSA-9709601.2
summation[Summation:9709618] The extreme N-terminus of BRCA2, involving amino acid residu...
(hasEvent)[Pathway:9709603] Impaired BRCA2 binding to PALB2 [Homo sapiens]
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