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Details on Person BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51

Class:Id	FailedReaction:9709571
_displayName	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
_doRelease	TRUE
_timestamp	2022-02-04 15:40:35
authored	[InstanceEdit:9709263] Orlic-Milacic, Marija, 2020-12-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9709572] Orlic-Milacic, Marija, 2020-12-15
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9763742] Orlic-Milacic, Marija, 2022-02-04
entityFunctionalStatus	[EntityFunctionalStatus:9763399] loss_of_function of BRCA2 mutants (RAD51 binding):SEM1 [nucleoplasm]
input	[Complex:5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5685231] p-T309-RAD51 [nucleoplasm] [Homo sapiens] [Complex:9763400] BRCA2 mutants (RAD51 binding):SEM1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9709578] Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control [LiteratureReference:9763128] Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats [LiteratureReference:9763127] Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
modified	[InstanceEdit:9709584] Orlic-Milacic, Marija, 2020-12-15 [InstanceEdit:9709592] Orlic-Milacic, Marija, 2020-12-15 [InstanceEdit:9709593] Orlic-Milacic, Marija, 2020-12-16 [InstanceEdit:9762644] Orlic-Milacic, Marija, 2022-01-27 [InstanceEdit:9763133] Orlic-Milacic, Marija, 2022-01-31 [InstanceEdit:9763134] Orlic-Milacic, Marija, 2022-01-31 [InstanceEdit:9763403] Orlic-Milacic, Marija, 2022-02-02 [InstanceEdit:9763682] Orlic-Milacic, Marija, 2022-02-03 [InstanceEdit:9763740] Orlic-Milacic, Marija, 2022-02-04 [InstanceEdit:9763743] Orlic-Milacic, Marija, 2022-02-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
normalReaction	[Reaction:5693561] RAD51 binds BRCA2 at resected DNA DSBs [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9763679] Liu, Jie, 2022-01-26 [InstanceEdit:9763678] Le, Hang Phuong, 2022-01-26 [InstanceEdit:9763681] Heyer, Wolf-Dietrich, 2022-01-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9709573] R-HSA-9709571.2
summation	[Summation:9709576] BRCA2 contains 8 BRC repeats in its middle region, which are...
(hasEvent)	[Pathway:9709570] Impaired BRCA2 binding to RAD51 [Homo sapiens]
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No pathways have been reviewed or authored by BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (9709571)