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Details on Person Defective BRCA2 does not translocate to the nucleus
| Class:Id | FailedReaction:9709268 |
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| _displayName | Defective BRCA2 does not translocate to the nucleus |
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| _doRelease | TRUE |
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| _timestamp | 2022-02-04 15:40:39 |
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| authored | [InstanceEdit:9709291] Orlic-Milacic, Marija, 2020-12-11 |
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| compartment | [Compartment:70101] cytosol |
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| created | [InstanceEdit:9709263] Orlic-Milacic, Marija, 2020-12-11 |
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| disease | [Disease:1500689] cancer |
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| edited | [InstanceEdit:9763742] Orlic-Milacic, Marija, 2022-02-04 |
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| entityFunctionalStatus | [EntityFunctionalStatus:9709285] loss_of_function of BRCA2 mutants (NLS):SEM1 [cytosol] |
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| input | [Complex:9763270] BRCA2 mutants (NLS):SEM1 [cytosol] [Homo sapiens] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:9709272] Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations
[LiteratureReference:9709293] A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer |
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| modified | [InstanceEdit:9709289] Orlic-Milacic, Marija, 2020-12-11
[InstanceEdit:9709301] Orlic-Milacic, Marija, 2020-12-12
[InstanceEdit:9763272] Orlic-Milacic, Marija, 2022-02-01
[InstanceEdit:9763682] Orlic-Milacic, Marija, 2022-02-03
[InstanceEdit:9763683] Orlic-Milacic, Marija, 2022-02-03
[InstanceEdit:9763732] Orlic-Milacic, Marija, 2022-02-04
[InstanceEdit:9763742] Orlic-Milacic, Marija, 2022-02-04
[InstanceEdit:9763743] Orlic-Milacic, Marija, 2022-02-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | Defective BRCA2 does not translocate to the nucleus |
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| normalReaction |
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| releaseDate | 2022-03-23 |
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| reviewed | [InstanceEdit:9763679] Liu, Jie, 2022-01-26
[InstanceEdit:9763678] Le, Hang Phuong, 2022-01-26
[InstanceEdit:9763681] Heyer, Wolf-Dietrich, 2022-01-26 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:9709278] R-HSA-9709268.2 |
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| summation | [Summation:9709287] Truncating mutations are the most frequent mutations seen in... |
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| (hasEvent) | [Pathway:9709275] Impaired BRCA2 translocation to the nucleus [Homo sapiens] |
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