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Details on Person SARS-CoV-2 6 binds NUP98:RAE1 within NPC

Class:Id	Reaction:9708889
_displayName	SARS-CoV-2 6 binds NUP98:RAE1 within NPC
_doRelease	TRUE
_timestamp	2022-03-01 03:13:16
authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:9708900] Shamovsky, Veronica, 2020-12-03
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
input	[Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] [Homo sapiens] [EntityWithAccessionedSequence:9708916] 6 [cytosol] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9708890] SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling [LiteratureReference:9730480] Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex [LiteratureReference:9756560] SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98 [LiteratureReference:9705013] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing [LiteratureReference:9756561] The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation
modified	[InstanceEdit:9708915] Shamovsky, Veronica, 2020-12-03 [InstanceEdit:9730472] Stephan, Ralf, 2021-05-07 [InstanceEdit:9731323] Stephan, Ralf, 2021-05-19 [InstanceEdit:9756577] Shamovsky, Veronica, 2021-10-15 [InstanceEdit:9757605] Shamovsky, Veronica, 2021-11-02 [InstanceEdit:9757617] Shamovsky, Veronica, 2021-11-03 [InstanceEdit:9766202] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9766342] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767649] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-2 6 binds NUP98:RAE1 within NPC
output	[Complex:9708891] 6:NPC [nuclear envelope] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9727293] 6 localizes to the nuclear envelope [Homo sapiens] [BlackBoxEvent:9727292] mRNA6 is translated to protein 6 [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9708912] R-HSA-9708889.2
summation	[Summation:9708887] Accessory protein ORF6 (6) of severe acute respiratory syndr...
(hasEvent)	[Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses [Homo sapiens] [Pathway:9711037] Microbial regulators of DDX58/IFIH1 signaling [Homo sapiens] [Pathway:9757473] Regulation of IFNA/IFNB signaling by microbial agent [Homo sapiens]
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No pathways have been reviewed or authored by SARS-CoV-2 6 binds NUP98:RAE1 within NPC (9708889)