Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The mitochondrial antiviral-signaling protein (MAVS, IPS-1) ...
| Class:Id | Summation:9708885 |
|---|---|
| _displayName | The mitochondrial antiviral-signaling protein (MAVS, IPS-1) ... |
| _timestamp | 2022-04-05 10:07:55 |
| created | [InstanceEdit:9708886] Shamovsky, Veronica, 2020-12-03 |
| literatureReference | [LiteratureReference:177847] IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction [LiteratureReference:1227961] Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3 [LiteratureReference:9708085] The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation [LiteratureReference:9708063] The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity [LiteratureReference:9708857] Negative regulation of MAVS-mediated innate immune response by ASC [LiteratureReference:9685266] MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3 [LiteratureReference:9712482] Right place, right time: localisation and assembly of the NLRP3 inflammasome |
| modified | [InstanceEdit:9712432] Shamovsky, Veronica, 2021-01-19 [InstanceEdit:9770499] Shamovsky, Veronica, 2022-04-05 |
| text | The mitochondrial antiviral-signaling protein (MAVS, IPS-1) is an integral protein of the mitochondrial outer membrane that tunes antiviral immune responses via recruiting various downstream effectors to the mitochondria. Upon viral infection, MAVS is activated by antiviral innate immune response receptor RIG-I (RIG-1, DDX58) and interferon (IFN)-induced helicase C domain-containing protein 1 (IFIH1, also known as MDA5), which leads to the upregulation of the interferon regulatory factor 3 (IRF3) & IRF7 and the nuclear factor kappa B (NF-kappaB) pathways. IRF3 & IRF7 facilitate type I interferon (IFN) production and antiviral responses (Kawai T et al. 2005; Seth RB et al. 2005). Activated NF-kappaB induces the transcription of NF-kappaB-dependent genes, such as NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) and pro- interleukin (IL)-1β. Immunoprecipitation experiments showed that Myc-tagged MAVS interacted with Flag-tagged NLRP3 upon expression in human embryonic kidney 293T (HEK293T) cells (Park S et al. 2013). MAVS interaction with NLRP3 depended on an N-terminal sequence of NLRP3 in HEK293T cells (Subramanian N et al. 2013). Further, endogenous MAVS associated with endogenous NLRP3 in Sendai virus-stimulated human monocyte-like THP-1cells (Park S et al. 2013). In the inactive state, NLRP3 resides mainly on the endoplasmic reticulum (ER) membrane and in the cytosol, but upon stimulation NLRP3 can associate with the mitochondrial membrane (reviewed by Hamilton C & Anand PK 2019). MAVS is thought to recruit NLRP3 to the mitochondria thereby promoting the mitochondrial NLRP3 inflammasome assembly and activation of caspase-1 (CASP1) (Subramanian N et al. 2013; Park S et al. 2013). MAVS was also found to bind the apoptosis-associated speck-like protein containing a CARD (ASC or PYCARD), an adaptor protein of the NLRP3 inflammasome complex (Guan K et al. 2015; Han Y et al. 2018). The interaction of NLRP3 with MAVS was found to downregulate MAVS-dependent type I IFN signaling in HEK293T and mouse bone-marrow-derived macrophages (BMDM) (Park S et al. 2013). These data suggest that MAVS tunes signaling pathways simultaneously in response to viral infection. This Reactome event describes recruitment of cytosolic NLRP3 to MAVS. |
| (summation) | [Reaction:9685270] NLRP3:SUGT1:HSP90 binds MAVS [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The mitochondrial antiviral-signaling protein (MAVS, IPS-1) ... (9708885)
