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Details on Person DHODH:FMN binds DHODH inhibitors

Class:Id	Reaction:9708759
_displayName	DHODH:FMN binds DHODH inhibitors
_doRelease	TRUE
_timestamp	2022-05-10 17:55:40
authored	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:70101] cytosol
created	[InstanceEdit:9708748] Jassal, Bijay, 2020-12-01
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input	[Complex:73534] DHODH:FMN [mitochondrial inner membrane] [Homo sapiens] [CandidateSet:9708729] DHODH inhibitors [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9708739] The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase [LiteratureReference:9708758] Leflunomide: mode of action in the treatment of rheumatoid arthritis [LiteratureReference:9708750] Teriflunomide, an inhibitor of dihydroorotate dehydrogenase for the potential oral treatment of multiple sclerosis [LiteratureReference:9708755] Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2 [LiteratureReference:9708764] Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection [LiteratureReference:9708769] A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial [LiteratureReference:9708772] COVID-19 in teriflunomide-treated patients with multiple sclerosis
modified	[InstanceEdit:9773229] Matthews, Lisa, 2022-05-03 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10 [InstanceEdit:9773858] Matthews, Lisa, 2022-05-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DHODH:FMN binds DHODH inhibitors
output	[Complex:9708760] DHODH:FMN:DHODH inhibitors [mitochondrial inner membrane] [Homo sapiens]
releaseDate	2022-06-09
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9708797] R-HSA-9708759.2
summation	[Summation:9708732] Dihydroorotate dehydrogenase (DHODH) is the fourth, and rate...
(hasEvent)	[Pathway:500753] Pyrimidine biosynthesis [Homo sapiens]
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No pathways have been reviewed or authored by DHODH:FMN binds DHODH inhibitors (9708759)