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Details on Person A small but significant fraction of XPO1 (CRM1) binds to BAC...
| Class:Id | Summation:9708422 |
|---|---|
| _displayName | A small but significant fraction of XPO1 (CRM1) binds to BAC... |
| _timestamp | 2021-01-11 10:20:29 |
| created | [InstanceEdit:9708426] Stephan, Ralf, 2020-11-30 |
| literatureReference | [LiteratureReference:9708432] Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1 |
| modified | [InstanceEdit:9711048] Stephan, Ralf, 2021-01-11 |
| text | A small but significant fraction of XPO1 (CRM1) binds to BACH1. Several cysteine–proline (CP) dipeptide sequence in BACH1 are involved in heme binding, they also contain a nuclear export signal. The simplest model is that this region is involved in a heme-regulated interaction with XPO1 that mediates nuclear export. While XPO1 bound to BACH1 in GST pull-down assays, the nature of this interaction has yet to be extensively characterized (Suzuki et al, 2004). |
| (summation) | [Reaction:9708430] XPO1 (CRM1) binds to BACH1:Hemes [Homo sapiens] |
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No pathways have been reviewed or authored by A small but significant fraction of XPO1 (CRM1) binds to BAC... (9708422)
