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Details on Person PDE5A dimer hydrolyses cGMP to GMP

Class:Id	Reaction:9708129
_displayName	PDE5A dimer hydrolyses cGMP to GMP
_timestamp	2020-11-25 11:10:12
catalystActivity	[CatalystActivity:9708091] 3',5'-cyclic-GMP phosphodiesterase activity of PDE5A dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9708123] Jassal, Bijay, 2020-11-25
input	[SimpleEntity:30991] cGMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9708113] Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase
modified	[InstanceEdit:9708182] Jassal, Bijay, 2020-11-25
name	PDE5A dimer hydrolyses cGMP to GMP
output	[SimpleEntity:113578] GMP [cytosol]
precedingEvent	[Reaction:392152] Soluble guanylate cyclase converts GTP to cGMP [Homo sapiens] [Reaction:392143] NO binds to Guanylate Cyclase [Homo sapiens]
regulatedBy	[PositiveRegulation:9708179] Positive regulation by 'Cyclic GMP-dependent protein kinases (PKGs) [cytosol]' [NegativeRegulation:9708180] Negative regulation by 'PP1 [cytosol]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9708176] R-HSA-9708129.1
summation	[Summation:9708125] Degradation of cyclic nucleotides such as cAMP and cGMP is c...
(hasEvent)	[Pathway:445355] Smooth Muscle Contraction [Homo sapiens]
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No pathways have been reviewed or authored by PDE5A dimer hydrolyses cGMP to GMP (9708129)