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Details on Person The mitochondrial antiviral signaling protein (MAVS) is acti...
| Class:Id | Summation:9708090 |
|---|---|
| _displayName | The mitochondrial antiviral signaling protein (MAVS) is acti... |
| _timestamp | 2022-07-02 04:04:33 |
| created | [InstanceEdit:9708089] Shamovsky, Veronica, 2020-11-24 |
| literatureReference | [LiteratureReference:9708085] The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation [LiteratureReference:9708063] The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity [LiteratureReference:9710589] MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response [LiteratureReference:9710590] Structural basis for the prion-like MAVS filaments in antiviral innate immunity [LiteratureReference:9712355] Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling [LiteratureReference:9712375] MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition [LiteratureReference:9712356] MCC950 closes the active conformation of NLRP3 to an inactive state |
| modified | [InstanceEdit:9710592] Shamovsky, Veronica, 2021-01-05 [InstanceEdit:9712304] Shamovsky, Veronica, 2021-01-18 [InstanceEdit:9794325] Shamovsky, Veronica, 2022-07-02 |
| text | The mitochondrial antiviral signaling protein (MAVS) is activated upon viral infection forming prion-like aggregates which are highly potent in activating downstream signaling pathways (Hou F et al. 2011; Xu H et al. 2014). The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) was shown to physically interact with MAVS (Subramanian N et al. 2013; Park S et al. 2013). MAVS is thought to recruit NLRP3 to the outer mitochondrial membrane promoting the oligomerization of NLRP3 (Park S et al. 2013). NLRP3 oligomerizes via its nucleotide-binding and oligomerization domain (NACHT, also known as NOD) (Duncan JA et al. 2007). NOD of NLRP3 displays ATPase activity that is required for NLRP3 oligomerization (Duncan JA et al. 2007). The specific NLRP3 inflammasome inhibitor MCC950 targets the Walker B motif within the NOD domain of NLRP3 and blocks ATP hydrolysis inhibiting NLRP3 oligomerization and activation (Coll RC et al. 2019; Tapia-Abellán A et al. 2019). The oligomerization of NLRP3 is thought to serve as a platform to faclitate the assembly of apoptosis-associated speck-like protein containing a CARD (ASC or PYCARD) monomers into a prion-like polymer (speck). |
| (summation) | [Polymerisation:9686277] NLRP3 oligomerizes [Homo sapiens] |
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