Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person After binding CSF3 (G-CSF), the CSF3 receptor CSF3R is inter...

Class:IdSummation:9707976
_displayNameAfter binding CSF3 (G-CSF), the CSF3 receptor CSF3R is inter...
_timestamp2020-11-27 03:04:10
created[InstanceEdit:9707968] May, Bruce, 2020-11-21
modified[InstanceEdit:9708247] May, Bruce, 2020-11-27
textAfter binding CSF3 (G-CSF), the CSF3 receptor CSF3R is internalized into endosomes (Aarts et al. 2004). Only a minor portion of CSF3R is located at the plasma membrane. Most CSF3R is located internally in the Golgi, endosomes, and lysosomes (Aarts et al. 2004). Endocytosis depends on a dileucine motif in the C-terminal region of CSF3R (inferred from mouse homologs).
(summation)[BlackBoxEvent:9705726] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed [Homo sapiens]
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