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Details on Person May, Bruce, 2020-11-21
| Class:Id | InstanceEdit:9707968 |
| _displayName | May, Bruce, 2020-11-21 |
| _timestamp | 2020-11-21 05:07:01 |
| author | [Person:203835] May, Bruce |
| dateTime | 2020-11-21 05:06:51 |
| (created) | [Summation:9707966] A ubiquitin E3 ligase complex assembled by SOCS3 or SOCS1 po... [Summation:9707967] Socs1 and Socs3 recruit Elongin B (Elob), Elongin C (Eloc), ... [BlackBoxEvent:9707969] Socs1,3 ubiquitinates Csf3r in Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:Cul5:EloB:EloC:Rnf7 [Mus musculus] [NegativeRegulation:9707970] Negative regulation by 'SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane]' [BlackBoxEvent:9707971] Csf3 dimer:2xK48polyUb-K655,p-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 translocates from the endocytic vesicle membrane to the lysosomal membrane [Mus musculus] [Reaction:9707972] Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7 [Mus musculus] [RegulationReference:9707973] Negative regulation by 'SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane]' Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity [Summation:9707974] SOCS1 and SOCS3 recruit Elongin B (ELOB), Elongin C (ELOC), ... [Summation:9707975] Polyubiquitinated CSF3R, believed to be in a complex with wi... [Summation:9707976] After binding CSF3 (G-CSF), the CSF3 receptor CSF3R is inter... |
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No pathways have been reviewed or authored by May, Bruce, 2020-11-21 (9707968)