Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Heme signaling

Class:IdPathwayDiagram:9707744
_displayNameDiagram of Heme signaling
_timestamp2022-03-02 12:25:52
created[InstanceEdit:9707743] Stephan, Ralf, 2020-11-19
height1540
modified[InstanceEdit:9707852] Stephan, Ralf, 2020-11-20
[InstanceEdit:9707996] Jassal, Bijay, 2020-11-23
[InstanceEdit:9708426] Stephan, Ralf, 2020-11-30
[InstanceEdit:9708858] Stephan, Ralf, 2020-12-02
[InstanceEdit:9709946] Stephan, Ralf, 2020-12-18
[InstanceEdit:9710015] Jassal, Bijay, 2020-12-23
[InstanceEdit:9710016] Jassal, Bijay, 2020-12-24
[InstanceEdit:9710017] Jassal, Bijay, 2020-12-24
[InstanceEdit:9711130] Stephan, Ralf, 2021-01-13
[InstanceEdit:9716625] Matthews, Lisa, 2021-02-23
[InstanceEdit:9716684] Jassal, Bijay, 2021-02-23
[InstanceEdit:9716696] Stephan, Ralf, 2021-02-24
[InstanceEdit:9716698] Stephan, Ralf, 2021-02-24
[InstanceEdit:9767892] Matthews, Lisa, 2022-03-02
[InstanceEdit:9767903] Matthews, Lisa, 2022-03-02
representedPathway[Pathway:9707616] Heme signaling [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="1042" reactomeDiagramId="9707744"> <Properties> <displayName>Diagram of Heme signaling</displayName> </Properties> <Nodes> <org.gk.render.RenderableChemical id="23" reactomeId="351629" position="173 217" bounds="148 202 51 30" textPosition="152 206"> <Properties> <displayName>H2O2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="24" reactomeId="9707636" position="1125 224" bounds="1068 211 114 27" textPosition="1069 213"> <Properties> <displayName>oxidized LDL,HDL</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="25" reactomeId="9707624" position="479 236" bounds="446 221 66 30" textPosition="450 225"> <Properties> <displayName>hydroxyl</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="26" reactomeId="917955" position="771 145" bounds="747 130 49 30" textPosition="751 134"> <Properties> <displayName>FeHM</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="28" reactomeId="9707678" position="1097 448" bounds="1039 437 116 22" textPosition="1039 437" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TLR4:Hemes:LY96</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="29" reactomeId="9707486" position="1050 131" bounds="1019 119 63 25" textPosition="1022 120"> <Properties> <displayName>LDL,HDL</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="31" reactomeId="2168866" position="476 94" bounds="453 83 47 22" textPosition="453 83" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MetHb</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="32" reactomeId="9707658" position="935 275" bounds="916 264 38 22" textPosition="916 264"> <Properties> <displayName>LY96</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="33" reactomeId="917877" position="791 238" bounds="767 223 49 30" textPosition="771 227" lineWidth="1.0"> <Properties> <displayName>heme</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="36" reactomeId="9707530" position="919 368" bounds="878 357 82 22" textPosition="878 357" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Hemes:LY96</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="37" reactomeId="166045" position="925 449" bounds="860 438 130 22" textPosition="860 438"> <Properties> <displayName>2xN4GlycoAsn-TLR4</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.12307692307692308" relativeY="0.0" label="G" trackId="0" reactomeId="3322083" /> <org.gk.render.RenderableFeature relativeX="0.24615384615384617" relativeY="0.0" label="G" trackId="0" reactomeId="3322088" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="38" reactomeId="9707647" position="487 161" bounds="450 146 75 30" textPosition="454 150"> <Properties> <displayName>hydroxide</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="40" reactomeId="2168856" position="751 46" bounds="727 35 49 22" textPosition="727 35" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ApoHb</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="41" reactomeId="9707672" position="153 105" bounds="97 90 113 30" textPosition="102 98" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ferrohemoglobin</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="55" reactomeId="5684807" position="748 453" bounds="703 442 91 22" textPosition="703 442" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CLEC1B dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="56" reactomeId="9707550" position="630 453" bounds="583 435 95 36" textPosition="583 435" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CLEC1B dimer:Hemes</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="67" reactomeId="70101" position="828 989" bounds="26 447 1604 1085" textPosition="67 464" bgColor="250 240 240" lineColor="255 153 102" insets="39 457 1577 1064"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="28" /> <Component id="37" /> <Component id="55" /> <Component id="56" /> <Component id="62" /> <Component id="84" /> <Component id="152" /> <Component id="661" /> <Component id="670" /> <Component id="681" /> <Component id="883" /> <Component id="884" /> <Component id="995" /> <Component id="996" /> <Component id="997" /> <Component id="1029" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="87" reactomeId="9707674" position="392 571" bounds="363 560 59 22" textPosition="363 560" /> <org.gk.render.RenderableComplex id="88" reactomeId="9707603" position="515 573" bounds="464 562 103 22" textPosition="464 562" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableEntitySet id="94" reactomeId="9707575" position="528 916" bounds="504 905 49 22" textPosition="504 905" /> <org.gk.render.RenderableProtein id="100" reactomeId="9707688" position="353 1073" bounds="329 1062 49 22" textPosition="329 1062"> <Properties> <displayName>BACH1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="101" reactomeId="1008242" position="225 1062" bounds="200 1051 50 22" textPosition="205 1051"> <Properties> <displayName>MAFK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="102" reactomeId="9707629" position="345 935" bounds="300 924 91 22" textPosition="303 924" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BACH1:MAFK</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="122" reactomeId="9707680" position="491 1042" bounds="445 1031 93 22" textPosition="445 1031" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BACH1:Hemes</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="151" reactomeId="9707310" position="679 311" bounds="655 300 49 22" textPosition="655 300" lineWidth="1.0" /> <org.gk.render.RenderableEntitySet id="152" reactomeId="9707308" position="459 498" bounds="435 487 49 22" textPosition="435 487" lineWidth="1.0"> <Properties> <displayName>Hemes</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="251" reactomeId="5640173" position="761 638" bounds="721 613 80 51" textPosition="721 640"> <Properties> <displayName>ARNTL gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="252" reactomeId="442501" position="825 854" bounds="800 843 51 22" textPosition="800 843"> <Properties> <displayName>NCOR1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="253" reactomeId="1368125" position="825 787" bounds="783 772 85 30" textPosition="787 776"> <Properties> <displayName>ferriheme b</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="254" reactomeId="442464" position="825 928" bounds="800 917 51 22" textPosition="800 917"> <Properties> <displayName>HDAC3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="255" reactomeId="375499" position="825 986" bounds="800 975 51 22" textPosition="800 975"> <Properties> <displayName>NR1D1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="256" reactomeId="5663269" position="636 604" bounds="570 579 133 50" textPosition="570 579" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1D1:heme:Corepressors:ARNTL gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="658" reactomeId="5640211" position="996 697" bounds="956 672 80 51" textPosition="956 699"> <Properties> <displayName>CLOCK gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="659" reactomeId="5663248" position="954 648" bounds="888 623 133 50" textPosition="888 623" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1D1:heme:Corepressors:CLOCK gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="661" reactomeId="400392" position="1064 509" bounds="1037 498 55 23" textPosition="1041 498"> <Properties> <displayName>CLOCK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="662" reactomeId="5656531" position="1130 643" bounds="1112 632 36 22" textPosition="1112 632"> <Properties> <displayName>RAI1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="663" reactomeId="427531" position="944 600" bounds="923 589 42 22" textPosition="923 589"> <Properties> <displayName>SIRT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="670" reactomeId="400353" position="815 501" bounds="791 490 48 22" textPosition="791 490"> <Properties> <displayName>ARNTL</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="678" reactomeId="5640176" position="1140 776" bounds="1101 751 79 51" textPosition="1101 778"> <Properties> <displayName>NPAS2 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="679" reactomeId="5663274" position="1009 805" bounds="943 780 132 50" textPosition="943 780" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1D1:heme:Corepressors:NPAS2 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="681" reactomeId="400314" position="1191 522" bounds="1168 511 47 22" textPosition="1168 511"> <Properties> <displayName>NPAS2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="682" reactomeId="400154" position="1329 673" bounds="1267 649 124 48" textPosition="1286 647" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PPARA:RXRA Coactivator complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="683" reactomeId="5663257" position="1350 739" bounds="1285 721 130 36" textPosition="1285 721" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RORA:EP300:NPAS2 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="688" reactomeId="5641202" position="774 1178" bounds="733 1140 83 51" textPosition="733 1167"> <Properties> <displayName>NR1D1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="689" reactomeId="5663262" position="756 1062" bounds="711 1037 91 50" textPosition="711 1037" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1D1:heme:Corepressors:NR1D1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="691" reactomeId="5663173" position="968 1097" bounds="904 1075 129 44" textPosition="906 1083" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-BMAL1:p-CLOCK,NPAS2:NR1D1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="692" reactomeId="5663260" position="945 1180" bounds="883 1162 124 36" textPosition="888 1162" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RORA:Coactivator:NR1D1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="700" reactomeId="4686147" position="1237 1017" bounds="1185 979 104 51" textPosition="1185 1006"> <Properties> <displayName>PPARGC1A gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="701" reactomeId="5663272" position="1200 944" bounds="1148 919 104 50" textPosition="1148 919" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1D1:heme:Corepressors:PPARGC1A gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="709" reactomeId="442481" position="1301 841" bounds="1265 830 72 22" textPosition="1265 830"> <Properties> <displayName>PPARGC1A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="710" reactomeId="1592227" position="1452 929" bounds="1409 918 87 22" textPosition="1409 918"> <Properties> <displayName>p-PPARGC1A</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="711" reactomeId="8931947" position="1464 986" bounds="1412 961 104 50" textPosition="1412 961" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S133-CREB:CRTC1,2,3:PPARGC1A gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="712" reactomeId="450243" position="1444 1077" bounds="1378 1060 132 34" textPosition="1388 1066"> <Properties> <displayName>p-T69,T71-ATF2</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.12121212121212122" relativeY="0.0" label="P" trackId="0" reactomeId="168386" /> <org.gk.render.RenderableFeature relativeX="0.24242424242424243" relativeY="0.0" label="P" trackId="0" reactomeId="450347" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="713" reactomeId="1605560" position="1411 870" bounds="1347 859 128 22" textPosition="1347 859" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MEF2C,D:PPARGC1A</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="883" reactomeId="7660" position="823 906" bounds="74 567 1499 679" textPosition="89 590" bgColor="250 240 240" lineColor="255 153 102" insets="84 577 1479 661"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="94" /> <Component id="99" /> <Component id="100" /> <Component id="101" /> <Component id="102" /> <Component id="116" /> <Component id="122" /> <Component id="121" /> <Component id="250" /> <Component id="251" /> <Component id="252" /> <Component id="253" /> <Component id="254" /> <Component id="255" /> <Component id="256" /> <Component id="259" /> <Component id="657" /> <Component id="658" /> <Component id="659" /> <Component id="660" /> <Component id="662" /> <Component id="663" /> <Component id="669" /> <Component id="677" /> <Component id="678" /> <Component id="679" /> <Component id="682" /> <Component id="683" /> <Component id="680" /> <Component id="687" /> <Component id="688" /> <Component id="689" /> <Component id="690" /> <Component id="691" /> <Component id="692" /> <Component id="699" /> <Component id="700" /> <Component id="701" /> <Component id="708" /> <Component id="709" /> <Component id="710" /> <Component id="711" /> <Component id="712" /> <Component id="713" /> <Component id="87" /> <Component id="88" /> <Component id="885" /> <Component id="985" /> <Component id="986" /> <Component id="988" /> <Component id="987" /> <Component id="1016" /> <Component id="1017" /> <Component id="1018" /> <Component id="1028" /> <Component id="1036" /> <Component id="1037" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="884" reactomeId="200673" position="461 452" bounds="431 441 61 22" textPosition="431 441"> <Properties> <displayName>SLC46A1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="885" reactomeId="5663268" position="853 709" bounds="793 686 121 46" textPosition="797 696" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RORA:Coactivator:ARNTL gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="986" reactomeId="9707849" position="464 727" bounds="413 716 103 22" textPosition="413 716" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PGRMC2:Hemes</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="988" reactomeId="9707859" position="320 787" bounds="291 776 59 22" textPosition="291 776"> <Properties> <displayName>PGRMC2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="989" reactomeId="9706826" position="261 548" bounds="216 537 91 22" textPosition="216 537" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>HMOX1 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="995" reactomeId="17957" position="288 510" bounds="228 467 120 86" textPosition="232 486" bgColor="250 240 240" lineColor="255 153 102" insets="236 476 103 67"> <Properties> <displayName>endoplasmic reticulum lumen</displayName> </Properties> <Components> <Component id="989" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.ProcessNode id="996" reactomeId="189445" position="117 524" bounds="58 496 118 56" textPosition="66 502"> <Properties> <displayName>Metabolism of porphyrins</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="1017" reactomeId="165529" position="313 1115" bounds="293 1104 41 22" textPosition="293 1104"> <Properties> <displayName>XPO1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1018" reactomeId="9708425" position="395 1202" bounds="331 1191 129 22" textPosition="331 1191" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>XPO1:BACH1:Hemes</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1029" reactomeId="9708433" position="398 1289" bounds="334 1278 129 22" textPosition="334 1278" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="1031" reactomeId="9709322" position="285 216" bounds="264 205 43 22" textPosition="264 205" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>COHb</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="1033" reactomeId="2173782" position="383 312" bounds="270 280 227 64" textPosition="276 290"> <Properties> <displayName>Binding and Uptake of Ligands by Scavenger Receptors</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableGene id="1036" reactomeId="6789487" position="169 1007" bounds="127 982 85 51" textPosition="127 1009"> <Properties> <displayName>HMOX1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1037" reactomeId="9766987" position="309 882" bounds="257 871 104 23" textPosition="257 872" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-NFE2L2:MAFK</displayName> </Properties> </org.gk.render.RenderableComplex> </Nodes> <Edges> <org.gk.render.RenderableReaction id="27" reactomeId="9707594" points="847 314, 847 315, 904 354" position="847 315" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="32" points="913 283" /> <Input id="151" points="710 311" /> </Inputs> <Outputs> <Output id="36" /> </Outputs> <Properties> <displayName>Hemes bind LY96</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="30" reactomeId="9707659" points="1001 406, 1001 405, 1072 434" position="1001 405" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="36" points="942 382" /> <Input id="37" points="944 435" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> <Properties> <displayName>Hemes:LY96 activates TLR4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="34" reactomeId="9707504" points="239 162, 284 163, 326 161" position="284 163" lineWidth="1.0"> <Inputs> <Input id="23" stoichiometry="4" points="191 199" /> <Input id="41" points="175 123" /> </Inputs> <Outputs> <Output id="25" stoichiometry="4" points="448 218" /> <Output id="38" stoichiometry="4" points="447 161" /> <Output id="31" points="450 104" /> </Outputs> <Inhibitors> <Inhibitor id="1031" points="284 202" /> </Inhibitors> <Properties> <displayName>H2O2 oxidises ferrohemoglobin to MetHb</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="35" reactomeId="9707586" points="922 164, 923 188, 923 212" position="923 188" lineWidth="1.0"> <Inputs> <Input id="26" points="799 148" /> <Input id="29" points="1013 139" /> </Inputs> <Outputs> <Output id="24" points="1062 220" /> <Output id="33" points="819 233" /> </Outputs> <Properties> <displayName>FeHM oxidises LDL,HDL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="39" reactomeId="9707516" points="503 94, 625 94, 625 93" position="625 94" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="31" /> </Inputs> <Outputs> <Output id="26" points="744 136" /> <Output id="40" stoichiometry="2" points="724 55" /> </Outputs> <Properties> <displayName>FeHM dissociates from MetHb</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="54" reactomeId="9707505" points="679 389, 679 390, 644 432" position="679 390" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="151" points="679 328" /> <Input id="55" points="736 439" /> </Inputs> <Outputs> <Output id="56" /> </Outputs> <Properties> <displayName>Hemes bind to CLEC1B dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="62" reactomeId="917870" points="666 328, 524 452, 474 481" position="524 452" lineWidth="1.0"> <Inputs> <Input id="151" /> </Inputs> <Outputs> <Output id="152" /> </Outputs> <Catalysts> <Catalyst id="884" points="495 452" /> </Catalysts> <Properties> <displayName>SLC46A1 transports hemes from extracellular region to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="84" reactomeId="9707683" points="445 536, 444 537, 493 559" position="444 537" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="152" points="454 515" /> <Input id="87" points="408 557" /> </Inputs> <Outputs> <Output id="88" /> </Outputs> <Properties> <displayName>PGRMC2 binds Hemes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="99" reactomeId="9707690" points="300 1041, 311 992, 338 949" position="311 992" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="100" points="334 1059" /> <Input id="101" points="253 1055" /> </Inputs> <Outputs> <Output id="102" /> </Outputs> <Properties> <displayName>BACH1 binds MAFK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="116" reactomeId="9707645" points="221 984, 221 935, 259 562" position="221 935" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1036" /> </Inputs> <Outputs> <Output id="989" /> </Outputs> <Inhibitors> <Inhibitor id="102" points="297 935" /> </Inhibitors> <Activators> <Activator id="1037" points="289 897" /> </Activators> <Properties> <displayName>HMOX1 gene produces HMOX1 dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="121" reactomeId="9707523" points="452 953, 451 952, 427 1002" position="451 952" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="102" points="394 942" /> <Input id="94" points="505 933" /> </Inputs> <Outputs> <Output id="101" points="235 1048, 259 1025" /> <Output id="122" points="473 1028" /> </Outputs> <Properties> <displayName>Hemes bind to BACH1:MAFK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="250" reactomeId="1368069" points="665 791, 664 790, 639 632" position="664 790" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="251" points="810 615, 814 670" /> <Input id="252" points="797 843" /> <Input id="253" points="780 801, 748 813" /> <Input id="254" points="816 914, 758 841" /> <Input id="255" points="819 972, 763 861" /> </Inputs> <Outputs> <Output id="256" /> </Outputs> <Properties> <displayName>NR1D1 (REV-ERBA) binds heme, the ARNTL gene, and recruits corepressors.</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="257" points="762 163, 685 294" position="723 228" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="26" /> </Inputs> <Outputs> <Output id="151" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="259" points="791 805, 559 905" position="675 855" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="253" /> </Inputs> <Outputs> <Output id="94" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="657" reactomeId="5663271" points="900 779, 901 778, 943 676" position="901 778" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="252" points="836 840" /> <Input id="253" points="871 782" /> <Input id="658" points="1045 674, 1045 721" /> <Input id="254" points="830 914" /> <Input id="255" points="833 972, 860 940" /> </Inputs> <Outputs> <Output id="659" /> </Outputs> <Properties> <displayName>NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="660" reactomeId="1368119" points="1045 674, 1062 623, 1063 524" position="1062 623" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="658" /> </Inputs> <Outputs> <Output id="661" /> </Outputs> <Inhibitors> <Inhibitor id="659" points="1024 632" /> </Inhibitors> <Activators> <Activator id="662" points="1109 637" /> <Activator id="663" points="968 604" /> </Activators> <Properties> <displayName>Expression of CLOCK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="669" reactomeId="400342" points="810 615, 816 598, 815 515" position="816 598" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="251" /> </Inputs> <Outputs> <Output id="670" /> </Outputs> <Inhibitors> <Inhibitor id="256" points="706 601" /> </Inhibitors> <Activators> <Activator id="885" points="845 683" /> <Activator id="663" points="920 599" /> </Activators> <Properties> <displayName>Expression of ARNTL (BMAL1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="677" reactomeId="5663245" points="1010 912, 1008 911, 1008 833" position="1008 911" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="252" points="839 868, 908 915" /> <Input id="253" points="835 805, 908 901" /> <Input id="678" points="1189 753, 1189 853" /> <Input id="254" points="854 925" /> <Input id="255" points="845 972, 908 941" /> </Inputs> <Outputs> <Output id="679" /> </Outputs> <Properties> <displayName>NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="680" reactomeId="1368065" points="1189 753, 1191 690, 1191 536" position="1191 690" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="678" /> </Inputs> <Outputs> <Output id="681" /> </Outputs> <Inhibitors> <Inhibitor id="679" points="1048 777" /> </Inhibitors> <Activators> <Activator id="682" points="1264 680" /> <Activator id="683" points="1291 718" /> </Activators> <Properties> <displayName>Expression of NPAS2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="687" reactomeId="5663265" points="605 1047, 607 1046, 708 1057" position="607 1046" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="252" points="817 868, 759 946" /> <Input id="253" points="817 805, 752 933" /> <Input id="688" points="825 1142" /> <Input id="254" points="804 942" /> <Input id="255" points="797 977, 769 968" /> </Inputs> <Outputs> <Output id="689" /> </Outputs> <Properties> <displayName>NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="690" reactomeId="549475" points="825 1142, 830 1071, 825 1000" position="830 1071" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="688" /> </Inputs> <Outputs> <Output id="255" /> </Outputs> <Inhibitors> <Inhibitor id="689" points="805 1067" /> </Inhibitors> <Activators> <Activator id="691" points="901 1084" /> <Activator id="692" points="926 1159" /> </Activators> <Properties> <displayName>Expression of NR1D1 (REV-ERBA)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="699" reactomeId="5663258" points="1106 1093, 1105 1093, 1184 972" position="1105 1093" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="252" points="833 868, 933 998" /> <Input id="253" points="833 805, 935 985" /> <Input id="254" points="838 942, 930 1011" /> <Input id="255" points="854 995" /> <Input id="700" points="1298 981, 1305 1054" /> </Inputs> <Outputs> <Output id="701" /> </Outputs> <Properties> <displayName>NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="708" reactomeId="1368140" points="1298 981, 1304 941, 1301 855" position="1304 941" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="700" /> </Inputs> <Outputs> <Output id="709" /> </Outputs> <Inhibitors> <Inhibitor id="701" points="1255 942" /> </Inhibitors> <Activators> <Activator id="710" points="1403 932" /> <Activator id="711" points="1409 971" /> <Activator id="712" points="1426 1057" /> <Activator id="713" points="1394 884" /> </Activators> <Properties> <displayName>Expression of PPARGC1A (PGC-1alpha)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="985" reactomeId="9707606" points="508 587, 460 661, 463 713" position="460 661" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="88" /> </Inputs> <Outputs> <Output id="986" /> </Outputs> <Properties> <displayName>PGRMC2:Hemes translocate to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="987" reactomeId="9707856" points="451 741, 423 763, 391 786" position="423 763" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="986" /> </Inputs> <Outputs> <Output id="988" points="353 786" /> <Output id="94" points="516 899" /> </Outputs> <Properties> <displayName>PGRMC2:Hemes dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="997" interactionType="Activate" points="213 539, 179 533" position="196 536" lineWidth="2.0"> <Inputs> <Input id="989" /> </Inputs> <Outputs> <Output id="996" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1016" reactomeId="9708430" points="395 1142, 395 1159, 395 1188" position="395 1159" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1017" points="337 1121" /> <Input id="122" points="480 1056" /> </Inputs> <Outputs> <Output id="1018" /> </Outputs> <Properties> <displayName>XPO1 (CRM1) binds to BACH1:Hemes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1028" reactomeId="9708423" points="395 1216, 396 1245, 397 1275" position="396 1245" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1018" /> </Inputs> <Outputs> <Output id="1029" /> </Outputs> <Properties> <displayName>XPO1:BACH1:Hemes are transported out of the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1034" interactionType="Activate" points="649 311, 500 311" position="574 311" lineWidth="2.0"> <Inputs> <Input id="151" /> </Inputs> <Outputs> <Output id="1033" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.EntitySetAndMemberLink id="1035" points="764 252, 694 294" position="729 273" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="33" /> </Inputs> <Outputs> <Output id="151" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> </Edges> <Pathways /> </Process>
width1638
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of Heme signaling (9707744)
Follow Reactome