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Details on Person Secreted LY96 (MD-2) is a large protein that confers lipopol...

Class:IdSummation:9707643
_displayNameSecreted LY96 (MD-2) is a large protein that confers lipopol...
_timestamp2020-11-20 15:36:07
created[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
literatureReference[LiteratureReference:9707617] Identification of a Heme Activation Site on the MD-2/TLR4 Complex
[LiteratureReference:9707660] Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4
modified[InstanceEdit:9707852] Stephan, Ralf, 2020-11-20
textSecreted LY96 (MD-2) is a large protein that confers lipopolysaccharide (LPS) sensitivity to Toll-like receptor 4 (TLR4). Hemes can bind to secreted LY96 at a different site than LPS, resulting in comparable TLR4 activation (Belcher et al, 2002; Visintin et al, 2001).
(summation)[Reaction:9707594] Hemes bind LY96 [Homo sapiens]
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