Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Heme binds to four cysteine-proline motifs in the C-terminal...

Class:IdSummation:9707520
_displayNameHeme binds to four cysteine-proline motifs in the C-terminal...
_timestamp2020-11-30 09:27:10
created[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
literatureReference[LiteratureReference:9707666] Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1
[LiteratureReference:9707681] Human heme oxygenase cDNA and induction of its mRNA by hemin
[LiteratureReference:9708432] Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1
modified[InstanceEdit:9708426] Stephan, Ralf, 2020-11-30
textHeme binds to four cysteine-proline motifs in the C-terminal region of BACH1 and inhibits the DNA-binding activity of BACH1-MAFK heterodimers resulting in HMOX1 induction. MAFK separates from the complex, and heme recruits nuclear exporters for BACH1 (Yoshida et al, 1988; Ogawa et al, 2001; Suzuki et al, 2004).
(summation)[Reaction:9707523] Hemes bind to BACH1:MAFK [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Heme binds to four cysteine-proline motifs in the C-terminal... (9707520)