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Details on Person H2O2 oxidises ferrohemoglobin to MetHb

Class:IdReaction:9707504
_displayNameH2O2 oxidises ferrohemoglobin to MetHb
_doReleaseTRUE
_timestamp2022-02-25 00:34:23
authored[InstanceEdit:9707640] Stephan, Ralf, 2020-11-12
compartment[Compartment:984] extracellular region
created[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
edited[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
input[Complex:9707672] ferrohemoglobin [extracellular region] [Homo sapiens]
[SimpleEntity:351629] H2O2 [extracellular region]
[SimpleEntity:351629] H2O2 [extracellular region]
[SimpleEntity:351629] H2O2 [extracellular region]
[SimpleEntity:351629] H2O2 [extracellular region]
isChimericFALSE
literatureReference[LiteratureReference:9707532] Hemoglobin. A biologic fenton reagent
[LiteratureReference:9707989] Biopreservation of red blood cells--the struggle with hemoglobin oxidation
modified[InstanceEdit:9707992] Stephan, Ralf, 2020-11-23
[InstanceEdit:9709348] Stephan, Ralf, 2020-12-14
[InstanceEdit:9713328] Stephan, Ralf, 2021-01-25
[InstanceEdit:9713665] Stephan, Ralf, 2021-01-29
[InstanceEdit:9767166] Rothfels, Karen, 2022-02-25
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameH2O2 oxidises ferrohemoglobin to MetHb
Hemoglobin is oxidized by hydrogen peroxide
negativePrecedingEvent[NegativePrecedingEvent:9767162] Futile Cycle: H2O2 reduces MetHb
output[Complex:2168866] MetHb [extracellular region] [Homo sapiens]
[SimpleEntity:9707647] hydroxide [extracellular region]
[SimpleEntity:9707647] hydroxide [extracellular region]
[SimpleEntity:9707647] hydroxide [extracellular region]
[SimpleEntity:9707647] hydroxide [extracellular region]
[SimpleEntity:9707624] hydroxyl [extracellular region]
[SimpleEntity:9707624] hydroxyl [extracellular region]
[SimpleEntity:9707624] hydroxyl [extracellular region]
[SimpleEntity:9707624] hydroxyl [extracellular region]
regulatedBy[NegativeRegulation:9709405] Negative regulation by 'COHb [extracellular region]'
regulationReference[RegulationReference:9709383] Negative regulation by 'CO:ferrohemoglobin [extracellular region]' Carbon monoxide promotes respiratory hemoproteins iron reduction using peroxides as electron donors
releaseDate2021-03-23
reviewed[InstanceEdit:9713327] Somers, Julia, 2021-01-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9707704] R-HSA-9707504.3
summation[Summation:9707534] Extracellular ferrous (Fe2+) hemoglobin (FeHM) is readily ox...
(hasEvent)[Pathway:9707564] Cytoprotection by HMOX1 [Homo sapiens]
[Pathway:9707616] Heme signaling [Homo sapiens]
(precedingEvent)[Reaction:9707516] FeHM dissociates from MetHb [Homo sapiens]
[Reaction:9709360] H2O2 reduces MetHb [Homo sapiens]
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