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Details on Person Transcription regulator protein BACH1 is a critical physiolo...

Class:IdSummation:9707503
_displayNameTranscription regulator protein BACH1 is a critical physiolo...
_timestamp2020-12-04 09:06:46
created[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
literatureReference[LiteratureReference:9707521] Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene
[LiteratureReference:9707697] Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells
modified[InstanceEdit:9708934] Stephan, Ralf, 2020-12-03
[InstanceEdit:9708956] Stephan, Ralf, 2020-12-04
textTranscription regulator protein BACH1 is a critical physiological repressor of heme oxygenase 1 (HMOX1). BACH1 binds to the multiple Maf recognition elements (MAREs) of HMOX1 enhancer MafK in vitro and represses its activity in vivo. BACH1 is inducible by hypoxia and IFN-gamma (Kitamuro et al, 2003; Sun et al, 2002).

NFE2L2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that activates transcription of a battery of cytoprotective genes by binding to the ARE (antioxidant response element). It is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. HMOX1 is one of the genes whose expression it activates (Huang et al, 2000; Reichard et al, 2007).
(summation)[BlackBoxEvent:9707645] HMOX1 gene produces HMOX1 dimer [Homo sapiens]
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