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Details on Person Endogenous androgens such as testosterone and dihydrotestost...
| Class:Id | Summation:9706750 |
|---|---|
| _displayName | Endogenous androgens such as testosterone and dihydrotestost... |
| _timestamp | 2020-11-09 15:18:40 |
| created | [InstanceEdit:9706780] Jassal, Bijay, 2020-11-09 |
| literatureReference | [LiteratureReference:9706729] Use of doping agents, particularly anabolic steroids, in sports and society [LiteratureReference:9706735] Pharmacology of anabolic steroids |
| modified | [InstanceEdit:9706832] Jassal, Bijay, 2020-11-09 |
| text | Endogenous androgens such as testosterone and dihydrotestosterone are steroid hormones that regulate the development and maintenance of male characteristics in vertebrates through their binding to the androgen receptor (AR) (Tóth & Zakár 1982, Askew et al. 2007, Brinkmann 2011). They are synthesised from cholesterol in the testes, ovaries and the adrenal glands. Synthetic androgen agonists (AR agonists) are used in androgen replacement therapy to counter the effects of male hypogonadism (diminished functional activity of the gonads) (Rey & Grinspon 2020), to help with menopausal symptoms (Marina et al. 2020), in delayed puberty, the prophylactic treatment of hereditary angioedema (Bork 2018), the treatment of endometriosis (Simitsidellis et al. 2018, Gibson et al. 2020), muscle wasting (Woerdeman & de Ronde 2011, von Haehling 2017), erectile dysfunction (Morgunov et al. 2007, Aversa et al. 2019), osteoporosis (Chen et al. 2019) and to treat breast cancer in women (Kono et al. 2016, Kono et al. 2017, Chen et al. 2020, Basaria et al. 2001, Shahidi 2001). Both natural and synthetic androgens can act as anabolic–androgenic steroids (AAS, commonly called anabolic steroids). AASs can contribute to increases in body weight, often as lean mass increases can see gains in muscular strength and performance enhancement. For these reasons, their use in sport has been banned because of the potential to gain unfair advantage in physical competitions (Sjöqvist et al. 2008, Kicman 2008). |
| (summation) | [Reaction:9705926] AR binds AR agonists [Homo sapiens] |
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