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Details on Person UniProt:B2RY71 Dnai3
| Class:Id | ReferenceGeneProduct:9706498 |
|---|---|
| _chainChangeLog | chain:1-923 for 9706498 added on Thu November 5 2020 |
| _displayName | UniProt:B2RY71 Dnai3 |
| _timestamp | 2023-11-03 15:47:06 |
| chain | chain:1-923 |
| checksum | 8CB13ECD97C37190 |
| comment | FUNCTION Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization (By similarity). Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (PubMed:30060180). May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells (PubMed:25498833).SUBUNIT Interacts with ACTR2; this interaction reduces binding of the Arp2/3 complex to the VCA domain of nucleation promoting factors (By similarity). Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains (PubMed:30060180). Found in a associated with the catalytic heavy chain DNAH2, the intermediate chain DNAI4, and the light chain DYNLT1 (PubMed:30060180).SUBCELLULAR LOCATION Strongly expressed in the testes (PubMed:26501274). Detected also in brain and lung tissues (PubMed:26501274).DISRUPTION PHENOTYPE Deficient mice shown no overt abnormalities in body size, development, behavior, or fertility. |
| created | [InstanceEdit:9706439] Weiser, JD |
| description | recommendedName: fullName evidence="7"Dynein axonemal intermediate chain 3 alternativeName: WD repeat-containing protein 63 |
| geneName | Dnai3 Wdr63 |
| identifier | B2RY71 |
| isSequenceChanged | FALSE |
| keyword | Coiled coil Cytoplasm Reference proteome Repeat WD repeat |
| modified | [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Dnai3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DNAI3_MOUSE |
| sequenceLength | 923 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9969458] Dnai3 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:B2RY71 Dnai3 (9706498)
