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Details on Person UniProt:Q9ULA0-1 DNPEP
| Class:Id | ReferenceIsoform:9706448 |
|---|---|
| _chainChangeLog | chain:1-485 for 9706448 added on Thu November 5 2020 |
| _displayName | UniProt:Q9ULA0-1 DNPEP |
| _timestamp | 2024-11-03 20:18:48 |
| chain | chain:1-485 |
| checksum | 522180921D0FBFA9 |
| comment | FUNCTION Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.CATALYTIC ACTIVITY Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.COFACTOR Binds 2 Zn(2+) ions per subunit.ACTIVITY REGULATION One of the zinc ions is readily exchangeable with other divalent cations such as manganese, which strongly stimulates the enzymatic activity.SUBUNIT Tetrahedron-shaped homododecamer built from six homodimers.INTERACTION Ubiquitous.SIMILARITY Belongs to the peptidase M18 family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:9706439] Weiser, JD |
| description | recommendedName: fullName evidence="4"Aspartyl aminopeptidase ecNumber evidence="3"3.4.11.21 |
| geneName | DNPEP ASPEP DAP |
| identifier | Q9ULA0 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative initiation Aminopeptidase Cytoplasm Hydrolase Metal-binding Metalloprotease Phosphoprotein Protease Proteomics identification Reference proteome Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DNPEP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962285] ENSEMBL:ENSG00000123992 DNPEP [Homo sapiens] |
| secondaryIdentifier | DNPEP_HUMAN Q9BW44 Q9NUV5 Q9NV55 |
| sequenceLength | 485 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9ULA0-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9ULA0-1 DNPEP (9706448)
